Human activities have more than doubled inputs of nitrogen (N) to terrestrial ecosystems worldwide (1). Until recently, most of this increase was focused in the developed regions of the world. With fertilizer consumption (2), fossil-fuel emissions (3), and biomass burning (4) rapidly increasing in less developed regions, sources and distribution of anthropogenic N now occur globally (5), as doe...

We consider the optimum north-south elongation for the Millimeter Array A con guration and interferometric arrays in general. The optimum elongation depends primarily on the observational requirements of the array, with a very weak dependance on the latitude. Assuming that the Millimeter Array A con guration will be used primarily for long integrations, we nd that the optimum north-south axis r...

Intracellular parasites manipulate host cell apoptosis in different ways either to increase their life span within infected cells or to spread infection. The present data provided information on the cellular changes taking place in spleen and peripheral blood during Plasmodium berghei-infection and indicated apoptosis mediated host immune response during infection. Our results suggested a signi...

3,4-Methylenedioxymethamphetamine (MDMA) is a widely abused illicit drug that can cause severe and even fatal adverse effects. However, interest remains for its possible clinical applications in posttraumatic stress disorder and anxiety treatment. Preclinical studies to determine MDMA’s safety are needed. We evaluated MDMA’s pharmacokinetics and metabolism in male rats receiving 2.5, 5, and 10 ...

The recently discovered SCFA-activated G-coupled protein receptors FFA receptor 2 and FFA receptor 3 are co-localised in L-cells with the anorexigenic ‘ileal brake’ gut hormone peptide YY, and also in adipocytes, with activation stimulating leptin release. Thus, SCFA such as acetate and propionate show promise as a candidate to increase satiety-enhancing properties of food. We therefore postula...

Parkinson disease (PD) is a neurodegenerative disease primarily characterized by cardinal motor manifestations and CNS pathology. Current drug therapies can often stabilize these cardinal motor symptoms, and attention has shifted to the other motor and nonmotor symptoms of PD that are resistant to drug therapy. Dysphagia in PD is perhaps the most important drug-resistant symptom because it lead...

BACKGROUND: Outpatient craniotomy, biopsy, and spinal decompression have been performed at our center for more than a decade. Early feasibility studies suggest that they are safe, successful, cost-effective, and well-tolerated by patients. However, a largescale study of this magnitude has not been performed. OBJECTIVE: To characterize postoperative complications and the rate of successful disch...

In London on September 11-12, 2000, the Royal Society—the independent scientifi c academy in Britain, the counterpart to the U.S. National Academy of Science—hosted a discussion meeting on the “Origins of HIV and the AIDS epidemic.” The brochure about the meeting gave this synopsis: “HIV-1 and HIV-2 causing AIDS are new human viruses of animal origin. When, how and why these cross-species infec...

Introduction Neurodisability is probably the most significant contributor to chronic surgical disability in African children. It involves primarily hydrocephalus (HC) and spina bifida (SB), which can occur in isolation or together. Other causes of neurodisability include encephaloceles, which are part of the spectrum of neural tube defects (NTDs). True cerebral palsy is primarily nonsurgical, a...