Abstract The World Health Organization’s Sustainable Development Goal 3.7 covers sexual and reproductive health to ensure universal access care services, including family planning, information & education the integration of into national strategies. Globally, infertility is one most frequent chronic diseases among men women age. Infertility associated with a number different risk factors fr...

Research in the field of neuropsychoimmunology has enabled the researchers to show that cytokines target the brain to organize a "sickness response," which is fever, activation of hypothalamuspituitary – adrenal axis and behavioural alterations that develop in sick individuals. Perypheral cytokines do not act directly on the brain; they trigger the production of cytokines in the brain parenchim...

Integral membrane proteins are generally believed to have unique membrane topologies. However, it has been suggested that dual-topology proteins that adopt a mixture of two opposite orientations in the membrane may exist. Here we show that the membrane orientations of five dual-topology candidates identified in Escherichia coli are highly sensitive to changes in the distribution of positively c...

Vulnerability to sudden service disruptions due to deliberate sabotage and terrorist attacks is one of the major threats of today. Whereas the design of reliable supply networks has received considerable attention in the last few decades, few authors have addressed the issue of optimizing security investments for existing, but vulnerable, systems. In this paper we consider a simple service/supp...

Nonalcoholic steatohepatitis (NASH), along with other forms of nonalcoholic fatty liver disease, is an increasingly common clinico-pathological syndrome. It is frequently associated with obesity, especially visceral fat, and type 2 diabetes, and is intimately related to markers of the insulin resistance syndrome. Both the prevalence and the severity of liver steatosis are related to body mass i...

The effect of neem, Azadirachta indica A. Juss, on ultrastructural alteration of larvae and puparia of the blow fly, Chrysomya megacephala (Fabricius) (Diptera: Calliphoridae) and house fly, Musca domestica (Linnaeus) (Diptera: Muscidae), was investigated in the laboratory by using neem extract containing 0.24% azadirachtin A. Larvae of both species exposed to single dipping with the neem produ...

In the present study, a total of 1,235 porcine serum samples were collected from 9 counties in Jilin Province (40°52'~46°18'N,121°38'~131°19'E), northeastern China from August to October 2013, and the seroprevalence of Toxoplasma gondii infection was tested by indirect haemagglutination assay (IHA). The results showed that antibodies to T. gondii were found in 19.1% (95% confidence interval [CI...

CXC chemokine receptor CXCR3 and/or its main three ligands CXCL9, CXCL10, andCXCL11 are highly upregulated in a variety of diseases. As such, considerable efforts have beenmade to develop small-molecule receptor CXCR3 antagonists, yielding distinct chemical classes of antagonists blocking binding and/or function of CXCR3 chemokines. Although it is suggested that these compounds bind in an allos...