The global pollution of environment urges the screening effective natural protectors for correc-tion toxic and genotoxic action xenobiotics. Medicinal herbs contain a complex biologically ac-tive compounds that are potential sources such protective agent. In current study mutagenic antimutagenic activity alcoholic extracts peppermint (Mentha piperita L.) thyme (Thymus vulgaris L.), family Lamia...

This study was designed to explore further the relationship between cell proliferation and the induction of early putative preneoplastic lesions by carcinogens. Rats were given a non-necrogenic dose of 1,2-dimethylhydrazine 24 hr before being subjected to partial hepatectomy. Beginning 4 hr later, hydrocortisone was injected 10 times at 4-hr intervals to delay progression through the cell cycle...

David Hicks, 2 Corey Oses, 2 Eric Gossett, 2 Geena Gomez, 2 Richard H. Taylor, 2, 3 Cormac Toher, 2 Michael J. Mehl, Ohad Levy, 2, 5 and Stefano Curtarolo 2, 6, ∗ Department of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina 27708, USA Center for Materials Genomics, Duke University, Durham, North Carolina 27708, USA Department of Materials Science and Engin...

ABSTRACT Introduction Hydrazines are highly toxic inorganic liquids that used as propellants in military and aviation industries, such the U.S. Air Force F-16 Emergency Power Unit SpaceX SuperDraco Rockets. The most commonly derivatives include hydrazine, monomethylhydrazine, 1,1-dimethylhydrazine (unsymmetrical dimethylhydrazine). Industrial workers close contact with hydrazines during routine...

The usefulness of nuclear anomalies (NA) as a short-term test for indication of carcinogens in the mouse colon has been suggested previously by experiments in which colon-specific carcinogens induced NA in the colon, whereas non-colon carcinogens were, in general, impotent in that organ. We have extended this work to other sites in the digestive tract of female C57BL/6 mice treated with gamma-r...

In this experiment, a segment of the left colon including the upper part of the rectum was transposed to the upper jejunum, and a segment of upper jejunum was transposed to the left colon of the same animal. In another group, the same colon and jejunum segments were transsected and reanastomosed in place. A third group served as a normal control. After a recovery period, weekly s.c. 1,2-symmetr...

In patients with ulcerative colitis, epidemiological work has suggested an association between low folate status and an increased risk of colonic neoplasia. The aim of the present study was to determine if experimental folate deficiency increases the likelihood of developing neoplasia in rats treated with the carcinogen dimethylhydrazine. Weanling male Sprague-Dawley rats were fed with an amino...

Cholesterol feeding of rats with colon cancer induced by dimethylhydrazine results in reduced survival and an increased incidence of metastatic colon cancer. As cholesterol may be implicated in the induction or maintenance of the metastatic process, an experiment was designed to determine whether rats with colon cancer would benefit from the removal of cholesterol from the diet. Female Wistar r...