Objectives: Development and differentiation of osteoclasts are regulated by three factors which belong to the family of tumor necrosis factor: RANK, RANKL, OPG. Interaction disorders of the RANKL/RANK/OPG system can be an element of the etiopathogenesis of postmenopausal osteoporosis. Aim of the study: To examine the frequency of alleles and genotypes of four polymorphisms: !163 A > G, !245 T >...

INTRODUCTION Non insulin dependent diabetes mellitus is the most common type of diabetes. Genetic factors, lipid profiles, hypertension are potential risk factors for diabetes mellitus. Adenosine binding cassette transporter proteins 1 (ABCA1) plays a role in cholesterol metabolism, especially high density lipoprotein (HDL-cholesterol). There are multiple mechanisms by which HDL-cholesterol can...

BACKGROUND Multiple variables influencing the sustained virologic response (SVR) in chronic hepatitis C have been evaluated. One of them is genetic polymorphism near the IL28B gene. OBJECTIVES The aim of this study was to evaluate the influence of IL28B genotypes on SVR rates in a group of patients with chronic hepatitis C from the western part of Romania. PATIENTS AND METHODS A retrospecti...

less known. We assessed the MTHFR polymorphism in a nonmatched case-control study: 107 consecutive thromboembolic patients (deep venous thrombosis and pulmonary embolism), aged 54 years (range 18 to 80) and 200 healthy donors (42 years, range 25 to 54). Venous blood samples in EDTA were obtained for DNA analysis by PCR. The amplified fragments were cut with TaqI which recognized the C→T substit...

PURPOSE Tumor antigen-specific monoclonal antibodies (mAb) block oncogenic signaling and induce Fcγ receptor (FcγR)-mediated cytotoxicity. However, the role of CD8(+) CTL and FcγR in initiating innate and adaptive immune responses in mAb-treated human patients with cancer is still emerging. EXPERIMENTAL DESIGN FcγRIIIa codon 158 polymorphism was correlated with survival in 107 cetuximab-treat...

Introduction: Considering the effectiveness of polymorphisms in the occurrence of respiratory diseases, it seems that these genetic variations in viral and microbial receptors can be effective in the occurrence and progression of the disease. The present study aimed to  assess the relationship between the C-159T polymorphism in the CD14 gene promoter and the severity of the disease in  Covid-19...