The life path and formation as a scientist of an outstanding in the field materials processing by pressure Sokolov Lev Nikolaevich is considered.

On the 100th anniversary of Alzheimer's lecture describing the clinicopathological entity which bears his eponym, this article reviews the major areas of progress in our understanding of the disease and outlines the many gaps still remaining. The progress toward effective mechanistic therapy is reviewed.

October 2021 marks the 100th anniversary of founding Department neurology and medical genetics at Perm State Medical University. The article presents a historical perspective, main clinical research achievements, development prospects for department.