background: laron syndrome, is a disease that treated by igf-1. this protein is a single chain and has three disulfide bonds. people with laron syndrome have low rates of cancer and diabetes, although they appear to be at increased risk of casual death due to their stature. igf-1 is synthesized by many tissues and is secreted from liver as an endocrine hormone which is transmitted to other tiss...

conclusions according to the high functionality of the produced recombinant vector, it seems a good applicable tool for making an indicator cell line in subsequent basic and drug studies. results recombinant vector, pgl4ltr-luc, has expression levels of more than 50 folds compared to the control when co-transfected with the tax expressing vector into hek 293t cells. moreover, cells display more...

The standard 2-norm SVM is known for its good performance in twoclass classi£cation. In this paper, we consider the 1-norm SVM. We argue that the 1-norm SVM may have some advantage over the standard 2-norm SVM, especially when there are redundant noise features. We also propose an ef£cient algorithm that computes the whole solution path of the 1-norm SVM, hence facilitates adaptive selection of...

The support vector machine (SVM) algorithm (Cortes and Vapnik, 1995) is probably the most widely used kernel learning algorithm. It achieves relatively robust pattern recognition performance using well-established concepts in optimization theory. Despite this mathematical classicism, the implementation of efficient SVM solvers has diverged from the classical methods of numerical optimization. T...

‎in this paper‎, ‎we introduce the structure of a groupoid associated to a vector field‎ ‎on a smooth manifold‎. ‎we show that in the case of the $1$-dimensional manifolds‎, ‎our‎ ‎groupoid has a‎ ‎smooth structure such that makes it into a lie groupoid‎. ‎using this approach‎, ‎we associated to‎ ‎every vector field an equivalence‎ ‎relation on the lie algebra of all vector fields on the smooth...