T-type calcium channels (T/Ca(v)3-channels) are implicated in various physiologic and pathophysiologic processes such as epilepsy, sleep disorders, hypertension, and cancer. T-channels are the target of endogenous signaling lipids including the endocannabinoid anandamide, the ω3-fatty acids, and the lipoamino-acids. However, the precise molecular mechanism by which these molecules inhibit T-cur...

Hepatic mitochondrial function, APOC-III, and LPL are potential targets for triglyceride (TG)-lowering drugs. After 3 weeks of dietary treatment with the compound 2-(tridec-12-yn-1-ylthio)acetic acid (1-triple TTA), the hepatic mitochondrial FA oxidation increased more than 5-fold in male Wistar rats. Gene expression analysis in liver showed significant downregulation of APOC-III and upregulati...

The time to antibiotic administration (TTA) has been proposed as a quality-of-care measure in febrile neutropenia (FN); however, few data regarding the impact of the TTA on the mortality of adult cancer patients with FN are available. The objective of this study was to determine whether the TTA is a predictor of mortality in adult cancer patients with FN. A prospective cohort study of all conse...

The coordination properties of the ligand 2,2'-bipyrimidine-4,4'-dicarboxylic acid (H2bpd) with lanthanide(III) ions (Ln = Eu, Tb, or Lu) were investigated. syntheses H2bpd and its salts, [K2(bpd)(H2O)2] (1) [(AlkNH)Lu(bpd)2] (Alk Et, Hex, en), are described. In presence LnCl3 salts Lu, Tb), formation [Ln(bpd)2]- [Ln(bpd)(H2O)x]+ species was assessed by 1H nuclear magnetic resonance (NMR), spec...

A series of complexes of europium (III)/gadolinium (III) with 2-thienyltrifluoroacetonate (HTTA), terephthalic acid (TPA) and phenanthroline (Phen) were synthesized by coprecipitation. The resulting complexes including Eu2(TPA)(TTA)4Phen2, Eu1.4Gd0.6(TPA)(TTA)4Phen2, Eu1.0Gd1.0(TPA)(TTA)4Phen2 and Eu0.8Gd1.2(TPA)(TTA)4Phen2 were characterized by elemental analysis, IR spectroscopy and thermal s...

Tetradecylthioacetic acid (TTA), which cannot be beta-oxidized, exerts growth-limiting properties in glioma cells. In order to investigate the importance of modulated lipid metabolism and alterations in mitochondrial properties in this cell death process, we incubated glioma cells both with TTA and the oxidizable fatty acid palmitic acid (PA), in the presence of L-carnitine and the carnitine pa...

Triangular temporal alopecia (TTA) is an asymptomatic, circumscribed, non-scarring form of alopecia that affects the temporal scalp. Although TTA is most often seen between ages two and nine, the condition has rarely been described in adults. If unrecognized, adulthood TTA can be misdiagnosed, leading to unnecessary steroid treatment. This case report describes TTA in an adult woman who had no ...

ABSTRACT Introduction: South Africa has a high prevalence of trauma causing significant healthcare and financial burden. Various scoring systems have been developed to guide team activation (TTA). To date, however, there are no standardised criteria for TTA. The aim this preliminary study was analyse the practice clinical judgement TTA when compared American College Surgeons Committee on Trauma...

We report the design and synthesis of a novel kind of organic-inorganic hybrid material via the incorporation of europium (III) β-diketonate complexes (Eu(TTA)3, TTA = 2-thenoyltrifluoroacetone) into one-dimensional (1D) porous boron nitride (BN) microfibers. The developed Eu(TTA)3@BN hybrid composites with typical 1D fibrous morphology exhibit bright visible red-light emission on UV illuminati...

Tetradecylthioacetic acid (TTA) is a hypolipidemic antioxidant with immunomodulating properties involving activation of peroxisome proliferator-activated receptors (PPARs) and proliferation of mitochondria. This study aimed to penetrate the effect of TTA on the development of atherosclerotic lesions in apolipoprotein (apo)-E(-/-) mice fed a high-fat diet containing 0.3% TTA for 12 weeks. These ...