Fluorescence probes based on excited state proton transfer (ESPT) have been recently developed for microheterogeneous media. The ESPT behaviour of a series of substituted naphthols (4-chl oro-1-naphthol, 5-amino-1-naphthol , 4-methoxy1-naphthol, 7-methoxy-2-naphthol , 3-amino-2-naphthol, 6-bromo-2naphthol and 1-bromo-2-naphthol) is investigated in liposomes, using steady state and time resolved...

In the title compound, C(10)H(9)NO, the amino and the hydr-oxy groups act both as a single donor and a single acceptor in hydrogen bonding. In the crystal, mol-ecules are connected via chains of inter-molecular ⋯N-H⋯O-H⋯ inter-actions, forming a two-dimensional polymeric structure resembling the hydrogen-bonded mol-ecular assembly found in the crystal structure of naphthalene-1,5-diol. Within t...

ÐSorption and transformation of 1-naphthol by a K-smectite (K-SWy-2) were studied using batch sorption isotherms, Fourier-transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD). The sorbents included three preparations of the reference smectite clay (SWy-2): (1) whole clay containing naturally occurring carbonate impurities, (2) SWy-2 with the removal of carbonate impurities, and (...

Substrates that are specific for certain UDP-glucuronosyltransferase (UGT) isoforms are usually used as specific inhibitors to identify UGT isoforms responsible for the glucuronidation of drugs. 1-Naphthol and 4-nitrophenol are probe substrates for human UGT1A6. In the present study, we found that UGT1A1-catalyzed estradiol 3-O-glucuronide formation and UGT1A4-catalyzed imipramine N-glucuronide...

The reaction of dimethyl acetylenedicarboxylate with OH-acid such as 2-naphthol in the presence of trimethyl or triphenyl phosphite under solvent-free conditions produce oxaphosphaphenanthrene derivatives in good yields. Also, the reaction of dimethyl acetylenedicarboxylate and trimethyl phosphite in the presence of 1-naphthol leads to succinate derivatives in excellent yields. Using triethyl p...

Benzo[b]cyclohexa-2,4-dien-1-one (4) and benzo[b]cyclohexa-2,5-dien-1-one (5), the two most stable keto tautomers of 1-naphthol (1), were generated in aqueous solution by Norrish Type II fission of 4- and 2-phenacyl-1-tetralone, respectively, and the pH-rate profiles of their enolization were measured by flash photolysis. Several isotopic exchange rates of 1 were measured in aqueous acid to det...

The polycyclic aromatic hydrocarbon naphthalene is an environmental pollutant, a component of jet fuel and, since 2000, has been reclassified as a potential human carcinogen. Few studies of the in vitro human metabolism of naphthalene are available and these focus primarily on lung metabolism. The current studies were performed to characterize naphthalene metabolism by human cytochromes P450 (C...

Urinary naphthol is an established human biomarker used for assessing both occupational and environmental exposure. However, 1-naphthol is a metabolite of the insecticide carbaryl while both the 1- and 2-isomers are metabolites of naphthalene. Thus, urinary 1-naphthol levels will reflect combined exposure to both substances, particularly at environmental levels. The interpretation of biomarkers...

The title compound, C(16)H(12)Cl(2)O, was synthesized from 1-naphthol and 1,2-dichloro-benzene with anhydrous aluminium chloride as a cataylst. In the mol-ecule, the two ring systems are approximately perpendicular to one other with a dihedral angle of 82.06 (4)°. There are two CH-type hydrogen bonds.

Abstract Background Quinolones and cephalosporins are antibiotic agents with activity against Gram-positive Gram-negative bacteria. They contain chromophores amine groups which electron-rich centres capable of donating electrons to electron-deficient compounds. A survey the literature revealed that 2, 4-dinitro-1-naphthol, a nitroaromatic useful in chemical synthesis, can accept charge transfer...