The 1,3-Dipolar cycloaddition reactions are the classic reaction in modern synthetic organic chemistry. The concept of these reactions was introduced by Huisgen and his co-workers in the early 1960’s. 1,3-Dipolar cycloaddition reactions are simple but powerful tool for the construction of five membered heterocycles such as isoxazoles, isoxazolines, pyrazoles, pyrazolones, 1,2,4-oxadiazolines et...

An efficient one-pot three-component procedure for the synthesis of new chiral spiro oxindolopyrrolidines/pyrrolizidines with highly regio- and diastereo-enantio, selective from 1,3-dipolar cycloaddition of azomethine ylides and chiral menthol-drived trans-cinnamic are described. The mechanism of the reaction is discussed on basis of the assignment of the absolute configuration of one of the cy...

In this research an effective and appropriate method has been developed for one-pot synthesis of new N-phenyl fulleroisoxazoline using Fe3O4@SiO2 nanoparticles as a green magnetically recyclable catalyst. The prepared catalytic samples were characterized by XRD, SEM, FT-IR and VSM. The products have been characterized by physical and spectroscopic data such as IR, 1H NMR, 13C NMR, and MS analyses.

The [2+3] dipolar cycloaddition of nitrile oxides to the double C = C bonds of thiophene-1, 1-dioxides leads to formation of the fused isoxazolines-2 (1, 2). Tumor growth inhibition of these compounds strongly depends on the nature of group IV A element increasing from slightly active tert-butyl derivatives to silicon and germanium containing analogues. The products of benzonitrile oxide cycloa...

1,3-dipolar cycloaddition reaction of 1 mol or 2 mol of dibenzalaceton with 1 mol of non-stabilized azomethinylides generated in situ by decarboxylative condensation of isatin and proline or sarcosine give the novel new spiro-oxindolo(pyrrolizidines/ pyrrolidines) instead of bis-spirooxindolo( pyrrolizidines/ pyrrolidines).

1,3-dipolar cycloaddition reaction of 1 mol or 2 mol of dibenzalaceton with 1 mol of non-stabilized azomethinylides generated in situ by decarboxylative condensation of isatin and proline or sarcosine give the novel new spiro-oxindolo(pyrrolizidines/ pyrrolidines) instead of bis-spirooxindolo( pyrrolizidines/ pyrrolidines).

The dual diene/1,3-dipolar character of 1-H-imidazole 3-oxide, HIO 1, allows this compound toparticipate in a competitive Diels-Alder (DA)/1,3-dipolar cycloaddition (13DC) reaction toward C=Sdouble bond of the electro-deficient sulfonyl methane SFM 2. The B3LYP/6-311++G(d,p) calculatedrelative Gibbs free energies indicate that among the studied 13DC and DA reactions, former iscompletely preferr...

chiral pyrrolidines and pyrrolizidines with spirooxindole ring systems are the central skeletons for numerous alkaloids and pharmacologically important compounds. gelesmine, pseudotabersonine, formosanine, isoformosanine, morroniside and mitraphylline are some of the alkaloids containing spirooxindole ring systems. derivatives of spirooxindole find very wide biological applications as anti micr...

the dual diene/1,3-dipolar character of 1-h-imidazole 3-oxide, hio 1, allows this compound toparticipate in a competitive diels-alder (da)/1,3-dipolar cycloaddition (13dc) reaction toward c=sdouble bond of the electro-deficient sulfonyl methane sfm 2. the b3lyp/6-311++g(d,p) calculatedrelative gibbs free energies indicate that among the studied 13dc and da reactions, former iscompletely preferr...