Rofecoxib was originally submitted as an NDA in November 1998 and approved by the Agency in May 1999 for the relief of sign and symptom of osteo-arthritis (OA) and for the management of acute pain and dysmenorrhea. The current approved maximum dose was 25 mg daily for OA and 50 mg daily for acute pain. The purpose of this supplemental NDA submission was to provide evidence for label revision to...

We evaluated the inducibility of nitrate-dependent Fe(II)-EDTA oxidation (NDFO) in non-growth, chloramphenicol-amended, resting-cell suspensions of Dechloromonas sp. strain UWNR4 and Acidovorax sp. strain 2AN. Cells previously incubated with Fe(II)-EDTA oxidized ca. 6-fold more Fe(II)-EDTA than cells previously incubated with Fe(III)-EDTA. This is the first report of induction of NDFO by Fe(II).

Maurizio Bifulco1 and Anna Maria Malfitano2* 1Dipartimento di Farmacia, Università di Salerno, Fisciano, Salerno, Italy 2Dipartimento di Medicina e Chirurgia, Università di Salerno Facoltà di Medicina, Baronissi, Salerno *Corresponding author: Anna Maria Malfitano Dipartimento di Medicina e Chirurgia, Università di Salerno Facoltà di Medicina, Baronissi, Salerno, Tel: 0039-089-969742; E-mail: a...

Neuronal acetylcholine nicotinic receptors (nAChRs) are targets for the development of novel treatments of brain diseases. However, adverse effects (for example, emesis or nausea) associated with high drug maximal exposures or C(max) at nAChRs often hinder the advancement of experimental compounds in clinical trials. Therefore, it is essential to explore the feasibility of maintaining exposures...

The gamma-ray blazar PKS 1510−089 has a highly superluminal milli-arcsecond jet at a position angle (PA) of −28 and an arcsecond jet with an initial PA of 155. With a ∆PA of 177 between the arcsecond and milliarcsecond jets, PKS 1510−089 is perhaps the most highly misaligned radio jet ever observed and serves as a graphic example of projection effects in a highly beamed relativistic jet. Here w...

P. D. Sreekanth*, N. Geethanjali, P. D. Sreedevi, Shakeel Ahmed, N. Ravi Kumar and P. D. Kamala Jayanthi National Research Centre for Cashew, Puttur 574 202, India Sri Krishnadevaraya University, Anantapur 515 003, India National Geophysical Research Institute, Hyderabad 500 007, India Central Plantation Crops Research Institute, Kasaragod 671 124, India Indian Institute of Horticulture Researc...

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Animals with hippocampal lesions, induced by aspiration, are inferior to cortical control and normal animals in providing some aspects of maternal care needed for the proper survival of their young. Pup survival of animals with hippocampal lesions is significantly lower than pup survival of cortical control and normal animals. Nest construction of dams with hippocampal lesions is inferior to th...