The PI3K/AKT pathway plays an important role in the initiation and progression of cancer, and the drug development efforts targeting this pathway with therapeutic interventions have been advanced by academic and industrial groups. However, the clinical outcome is moderate. Combination of inhibition of PI3K/AKT and other targeted agents became a feasible approach. In this study we assessed the c...

Lounela, Anu, Berglund, Eeva and Kallinen Timo (eds) 2019. Dwelling in Political Landscapes. Contemporary Anthropological Perspectives. Helsinki: SKS. Studia Fennica Anthropologica 4. 293 p. ISBN 978-951-858-087-7 (Print), 978-951-858-114-0 (PDF) 978-951-858-113-3 (EPUB). https://doi.org/10.21435/sfa.4.

32 GHz observations with the Effelsberg 100-m telescope revealed a highly polarized Galactic Centre filament: G0.087−0.087, running parallel to the well-known Arc structure. It has a similar flat spectrum, but it is an order of magnitude weaker. G0.087−0.087 is about 2.5 or 6.2 pc long and located at the western boundary of the expanding molecular cloud G0.11−0.11. This unusual cloud is also vi...

(L'efficacité des équipes de commandement militaires : un modèle et un instrument pour l'évaluation et l'amélioration) This Technical Report has been prepared as a result of a project on " Team Effectiveness " for the RTO Human Factors and Medicine Panel (HFM-087/RTG-023).

BACKGROUND Clostridium difficile is the major cause of nosocomial antibiotic-associated diarrhoea with the potential risk of progressing to severe clinical outcomes including death. It is not unusual for Clostridium difficile infection to progress to complications of toxic megacolon, bowel perforation and even Gram-negative sepsis following pathological changes in the intestinal mucosa. These c...

Eliahou, S., The 3x+ 1 problem: new lower bounds on nontrivial cycle lengths, Discrete Mathematics 118 (1993) 45556. Let 7’: N -+ N be the function defined by T(n) = n/2 if n is even, T(n) = (3n + 1)/2 if n is odd. We show, among other things, that any nontrivial cyclic orbit under iteration of T must contain at least 17 087 915 elements.