The prediction of thermo-mechanical behaviour of heterogeneous materials such as heat and moisture transport is strongly influenced by the uncertainty in parameters. Such materials occur e.g. in historic buildings, and the durability assessment of these therefore needs a reliable and probabilistic simulation of transport processes, which is related to the suitable identification of material par...

This report presents a motion planner for systems subject to kinematic and dynamic constraints. The former appear when kinematic loops are present in the system, such as in parallel manipulators, in robots that cooperate to achieve a given task, or in situations involving contacts with the environment. The latter are necessary to obtain realistic trajectories, taking into account the forces act...

Let X = {1,. . ., n) and Í" = {1,..., k), k < n. Let C(n, k) be the subsets of X which intersect Y, ordered by inclusion. Lih showed that C(n, k) has the Sperner property. Here it is shown that C(n, k) has several stronger properties. A nested chain decomposition is constructed for C(n, k) by bracketing. C(n, k) is shown to have the LYM property. A more general class of collections of subsets i...

Address all correspondence to Dr. S. H. Orkin, Children's Hospital Medical Center, Boston, MA 02115. Received for publication 16 November 1982 and in revised form 20 December 1982. INTRODUCTION Recombinant DNA methods have permitted characterization of specific mutations in disorders of fl-globin synthesis, the fi-thalassemias (1). The most common form of fl-thalassemia among Mediterranean pati...

Melanomas resist conventional chemotherapeutics, in part, through intrinsic disrespect of apoptotic checkpoint activation. In this study, using an unbiased genome-wide RNA interference screen, we identified RhoJ and its effector PAK1, as key modulators of melanoma cell sensitivity to DNA damage. We find that RhoJ activates PAK1 in response to drug-induced DNA damage, which then uncouples ATR fr...

Our story begins in a city far away from here and a long time ago. Several physicians held a “think-tank” and they began with a vision. They believed that there exists a body of knowledge that is unique to sports medicine. This dream evolved from the drawing board into a reality. These men understood anatomy, physiology, and—above all—patient care. These visionaries created the American Orthopa...