Platelet microparticles (PMPs) contribute to thrombogenesis but the effects of antiplatelet drugs on PMPs generation is undefined. The present study investigated the cellular events regulating PMPs shedding, testing in vitro platelet agonists and inhibitors. Platelet-rich plasma from healthy subjects was stimulated with arachidonic acid (AA), U46619, collagen type-I (10 and 1.5 μg/mL), epinephr...

New antibiotics, miyakamides A1, A2, B1, and B2, were isolated from the cultured broth of Aspergillus flavus Link var. columnaris FKI-0739 together with known compounds, parasiticolide A, hydroxyaspergillic acid, and kojic acid. The structure of miyakamide A1 is N-acetyl-L-phenylalanyl-N-methyl-L-phenylalanyl-(alphaZ)-alpha,beta-didehydrotryptamine, and miyakamide A2 is E isomer of A1 at didehy...

0739-5175/06/$20.00©2006IEEE B rain-computer interfaces (BCIs) hold the promise to restore mobility and independence to persons with paralysis. In spinal cord injury, brainstem stroke, and a host of neuromuscular disorders, the intact brain is “disconnected” from its intact target (such as a limb or the facial musculature), preventing mobility and—in locked-in syndrome [1] and severe amyotrophi...

Abstract Introduction Mild Cognitive Impairment (MCI) is defined as a noticeable decline in cognitive abilities that doesn't interfere with daily activities; MCI may be precursor of Alzheimer’s disease and related dementia. Elevated risk has been shown subjects obstructive sleep apnea (OSA) clinic population insomnia general population. OSA Insomnia both have high prevalence among members the W...

http://dx.doi.org/10.1016/j.jhydrol.2014.06.051 0022-1694/ 2014 Elsevier B.V. All rights reserved. Abbreviations: SWI, surface water inputs; ROS, rain on snow; SCA, snow covered area; SWE, snow water equivalent; RMSE, root mean squared error. ⇑ Corresponding author. Tel.: +1 (208) 921 1930. E-mail addresses: [email protected] (P.R. Kormos), [email protected] (D. Marks), jmcnamar@boises...