Treatment with vitamin D sterols can lower plasma parathyroid hormone (PTH) in many patients with secondary hyperparathyroidism due to end-stage renal disease, but hypercalcemia, hyperphosphatemia, or both often develop during treatment. As such, alternative therapeutic approaches to managing excess PTH secretion are needed. Calcimimetic agents directly inhibit PTH secretion by activating the c...

BACKGROUND The National Research Council has recommended development of polio antiviral drugs to assist in management of outbreaks and to mitigate adverse consequences of vaccination. V-073 is a small molecule poliovirus capsid inhibitor that is being developed for these purposes. Antiviral use raises the potential of treatment-emergent resistance. Understanding virological consequences of resi...

Over the past years, use of synthetic cannabinoids has become increasingly popular. To draw the right conclusions regarding new intake of these substances in situations of repeated urinary drug testing, knowledge of their elimination rate in urine is essential. We report data from consecutive urine specimens from five subjects after ingestion of synthetic cannabinoids. Urinary concentrations of...

C l i n M e d International Library Citation: Sherwell-Cabello S, Maffuz-Aziz A, Lopez-Hernández SN, Flores-Cortés ML, Bautista-Pina V, et al. (2016) Pigmented Paget Disease of the Nipple: A Rare Breast Cancer Presentation. Int J Cancer Clin Res 3:073 Received: March 03, 2016: Accepted: November 23, 2016: Published: November 26, 2016 Copyright: © 2016 Sherwell-Cabello S, et al. This is an open-...

A correction to this paper has been published: https://doi.org/10.1007/JHEP01(2022)073

The recreational use of synthetic cannabinoids has recently increased. This increase is due, in part, to the recent availability of inexpensive compound sold legally online in bulk. In particular, JWH-018 (1-pentyl-3-(1-naphthoyl)indole) and JWH-073 (1-butyl-3-(1-naphthoyl)indole) have been found in herbal blends marketed as alternatives to cannabis. Although these particular compounds have rec...

Recently, several reports demonstrated functional expression of calcium-sensing receptor (CaSR) in the heart. Initial reports found the CaSR to be present in the cardiomyocytes, in contrast a recent report have found the CaSR to be present in sheep fibroblasts of the heart. The calcimimetic drug AMG 073 is a pharmacological (allosteric) modulator of CaSR that is in clinical use for the treatmen...

1. T. Gubała, M. Bubak, P.M.A. Sloot; Semantic Integration of Collaborative Research Environments, In: M. Cannataro (Ed.) Handbook of Research on Computational Grid Technologies for Life Sciences, Biomedicine and Healthcare, chapter XXVI, pages 514-530, 2009, IGI Global. 2. M. Bubak, T. Gubała, M. Kasztelnik, M. Malawski: Building Collaborative Applications for System-level Science, In: W. Gent...

Background: Surgical site infections (SSIs) are the most common healthcare-associated infections (HAI) in lower-income countries. This is the first study to report the results of surveillance on SSI stratified by surgical procedure in seven Vietnamese cities. Methods: This was a prospective, active SSI surveillance study conducted from November 2008–December 2010 in seven hospitals using the U....