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We have previously shown that inhibitors of I B kinase (IKK ), including 4(2 -aminoethyl)amino-1,8-dimethylimidazo(1,2a)quinoxaline (BMS-345541), are efficacious against experimental arthritis in rodents. In our efforts to identify an analog as a clinical candidate for the treatment of autoimmune and inflammatory disorders, we have discovered the potent and highly selective IKK inhibitor 2-meth...
http://dx.doi.org/10.1016/j.engstruct.2014.10.028 0141-0296/ 2014 Elsevier Ltd. All rights reserved. ⇑ Corresponding author at: EPFL ENAC IIC EESD, GC B2 484 (Bâtiment GC), Station 18, 1015 Lausanne, Switzerland. E-mail addresses: [email protected] (J.P. Almeida), [email protected] (A.A. Correia), [email protected] (R. Pinho). 1 Address: LNEC-DE/NESDE, Av. do Brasil 101, 1700-066 Lisbon, Po...
Sílvia Barros, Eduardo Gallego, Alfredo Lorente, Isabel F. Gonçalves, Pedro Vaz, Héctor René Vega-Carrillo and Maria Zankl IST/CTN, Universidade Técnica de Lisboa, Estrada Nacional 10, ao km 139,7 2695-066 Bobadela LRS, Portugal; Departamento de Ingeniería Nuclear, Universidad Politécnica de Madrid, E-28006, Madrid, España; Unidad Académica de Estudios Nucleares de la Universidad Autónoma de Za...
301 Correspondence to: Paweł Maga, MD, PhD, Klinika Angiologii, Uniwersytet Jagielloński, Collegium Medicum, ul. Skawińska 8, 31-066 Kraków, Poland, phone: +48-12-430-52-66, fax: +48-12-430-50-62, e-mail: [email protected] Received: February 13, 2015. Revision accepted: February 18, 2015. Published online: February 20, 2015. Conflict of interest: none declared. Pol Arch Med Wewn. 2015; 125 (...
Vitaly Glushkov 1,* and Mel Levy 2,3,4 1 Department of Physics, Electronics and Computer Systems, Oles Honchar Dnepropetrovsk National University, av. Yu.Gagarin 72, Dnipropetrovsk 49010, Ukraine 2 Department of Chemistry, Duke University, Durham, NC 27708, USA; [email protected] 3 Department of Physics, North Carolina A&T State University, Greensboro, NC 27411, USA 4 Department of Chemistry, Tu...
Benjamin H. Rotstein,†,‡ Serge Zaretsky,† Vishal Rai,†,§ and Andrei K. Yudin*,† †Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario Canada, M5S 3H6 ‡Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, and Department of Radiology, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 021...
Equids are considered highly resistant to mycobacterial infections and clinical cases have been described in domestic horses only. Mycobacterium bovis is the most common species reported, although a single report exists of disease due to definitively diagnosed infection with Mycobacterium avium subsp. hominissuis in two domestic horses. This is the first report of a mycobacterial infection in a...
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