1257 In 1916, Baron Constantin von Economo, a Viennese neurologist, began to see patients with a new type of encephalitis that specifically attacked regions of the brain that regulate sleep and wakefulness. This disorder, which was eventually called encephalitis lethargica or von Economo’s sleeping sickness, swept through Europe and North America during the second decade of the twentieth centur...

BACKGROUND Amongst Sardinians the human leukocyte antigen (HLA) DRB1-DQB1 haplotypes *15:02-*06:01, *16:01-*05:02, *14:01-4-*05:03 are protective for multiple sclerosis (MS), while *13:03-*03:01, *04:05-*03:01, *03:01-*02:01, *15:01-*06:02 and Mycobacterium avium subspecies paratubercolosis (MAP) are predisposing factors. We studied the correlation between MAP and HLA. METHODS Five hundred th...

Background GSK is investigating an autologous TCR T-cell therapy for solid tumors that recognizes the cancer testis antigen, NY-ESO-1, presented on cell surface by specific HLA-A*02 sub-types. The aim of this study was to estimate number patients in US 2020 with genotype subtypes HLA-A*02:01, 02:05, 02:06 across selected types (invasive lung, ovarian, gastric, esophageal, invasive and in-situ b...

Abstract Activation of CD8 +T cells against pathogens and cancers involves the recognition antigenic peptides presented in complex with human leukocyte antigen (HLA) class-I proteins. Peptide binding to HLA-I proteins is coordinated by a multi-protein called peptide loading (PLC). Tapasin, key PLC component, facilitates optimization peptides. However, different allotypes have variable requireme...

Pemphigus vulgaris (PV) is an acquired autoimmune blistering disease characterized by the production of autoantibodies targeting desmosomal cadherins, primarily desmoglein 1 and 3, leading to acantholysis. The etiology PV multifactorial, including genetic susceptibility. This retrospective study aimed evaluate association HLA class II alleles examine impact PV-associated on concentration anti-d...

Water is an important asset for the maintenance of life and socioeconomic development. Aquatic environments have been anthropized, receiving a large polluting load, mainly from trace elements.This study investigates occurrence health risks caused by 15 elements in surface water João Leite stream. Health risk indices were evaluated as average daily dose (ADD), hazard quotient (HQ), index carcino...

SUBJECT: EXTRACORPOREAL SHOCK WAVE THERAPY (ESWT) FOR MUSCULOSKELETAL CONDITIONS AND SOFT TISSUE WOUNDS POLICY NUMBER: 2.01.31 CATEGORY: Technology Assessment EFFECTIVE DATE: 10/18/01 REVISED DATE: 02/21/02, 02/20/03, 02/19/04, 02/17/05, 12/15/05, 01/18/07, 10/18/07, 09/18/08, 08/20/09, 07/15/10, 06/16/11, 06/21/12, 08/15/13, 07/17/14, 06/18/15 PAGE: 1 OF: 8 • If the member's subscriber contrac...