We have previously reported that captopril stimulates thromboxane A2 synthesis in patients with essential hypertension. In the present study, the hypotensive effects of captopril and OKY-046, a selective inhibitor of thromboxane A2 synthetase, were studied in nine patients with essential hypertension to determine whether thromboxane A2 is involved in the regulation of blood pressure. A single o...

Crude extracts of three actinomycetes species belonging to Saccharopolyspora (TR 046 and TR 039) and Actinosynnema (TR 024) genera were screened for antibacterial activities against a panel of several bacterial strains. The extracts showed antibacterial activities against both gram-negative and gram-positive test bacteria with inhibition zones ranging from 8 to 28 mm (TR 046); 8 to15 mm (TR 039...

The therapeutic effect of a thromboxane A2 (TXA2) synthetase inhibitor on asthma is still controversial. This study was aimed at clarifying its effect on asthmatic reactions in guinea pigs. Both ovalbumin (OVA)- and platelet activating factor (PAF)-induced dual phase airway spasm and hyperreactivity in guinea pigs were used as the asthma model. Our results demonstrated that aerosol administrati...

We examined the effects of KW-3635, a thromboxane (TX) A2-receptor antagonist, and OKY-046, a TX synthetase inhibitor, on the prostaglandin (PG) I2 production in endothelium-intact and -injured guinea pig aorta and compared them with those of aspirin. In the endothelium-intact aorta, both the low (3 mg/kg) and the high (100 mg/kg) dose of aspirin similarly reduced the PGI2 production, as measur...

The characterisation of the risk of (new) chemicals to species/communities, when both the exposure/environmental concentration and effects (species sensitivity) are variable and uncertain, is the central issue in Probabilistic Environmental Risk Assessment. The spatial variability is one of the largest components of the total variability. This paper tries to explicitly account for this spatial ...

The mechanisms of excessive sputum production are only partially understood. We speculated that a selective thromboxane (Tx) A2 synthetase inhibitor, OKY-046, now used in the treatment of asthma in Japan, could decrease excess sputum production in patients with chronic airways disease. To test this hypothesis, we carried out a double-blind, placebo-controlled study of the effects of OKY-046, ad...

Cyclooxygenase products are released by chronic airway inflammation. Our working hypothesis for the present study was that prostanoids augment airway cough sensitivity. The effects of a cyclooxygenase inhibitor, indomethacin (100 mg.day-1 for 4 days), and a thromboxane synthesis inhibitor, OKY-046 (400 mg.day-1 for 4 days), on cough response to inhaled capsaicin were examined in eight patients ...

X iv :1 50 6. 06 09 1v 1 [ nl in .A O ] 1 9 Ju n 20 15 Noise-induced synchronization in bidirectionally coupled Type-I neurons Nishant Malik, B. Ashok, and J. Balakrishnan Potsdam Institute for Climate Impact Research, Telegrafenberg, 14412 Potsdam, Germany. Advanced Centre for Research in High Energy Materials (ACRHEM), University of Hyderabad, Central University PO, Gachi Bowli, Hyderabad 500...

ABSTRACT We have undertaken a systematic study of FR I and II radio galaxies with the upgraded Giant Metrewave Radio Telescope (uGMRT) MeerKAT. The main goal is to explore whether unprecedented few μJy sensitivity reached in range 550–1712 MHz at resolution ∼4–7 arcsec reveals new features emission which might need us revise our current classification scheme for classical galaxies. In this pape...

C l i n M e d International Library Citation: Ali F, Kaushik GN, Carr ND, Hayes E, Plax KL (2016) Screening for Urethral, Rectal and Pharyngeal Gonorrhea & Chlamydia among Asymptomatic Male Adolescents and Young Men who have Sex with Men. J Fam Med Dis Prev 2:046 Received: August 20, 2016: Accepted: November 04, 2016: Published: November 08, 2016 Copyright: © 2016 Ali F, et al. This is an open-...