We have recently discovered a supermassive binary black hole system with a projected separation between the two black holes of 7.3 parsecs in the radio galaxy 0402+379 (Rodriguez et al. 2006). This is the most compact supermassive binary black hole pair yet imaged by more than two orders of magnitude. We present Global VLBI observations at 1.3464 GHz of this radio galaxy, taken to improve the q...

Certain HLA-DR alleles confer strong susceptibility to the autoimmune disease rheumatoid arthritis (RA). We compared RA-associated alleles, HLA-DR*0401, HLA-DR*0404, and HLA-DR*0405, with closely related, non-RA-associated alleles, HLA-DR*0402 and HLA-DR*0403, to determine whether they differ in their interactions with the class II chaperone, invariant chain (Ii). Ii binds to class II molecules...

We have recently discovered a supermassive binary black hole system with a projected separation between the two black holes of 7.3 parsecs in the radio galaxy 0402+379 (Rodriguez et al. 2006). This is the most compact supermassive binary black hole pair yet imaged by more than two orders of magnitude. We present Global VLBI observations at 1.3464 GHz of this radio galaxy, taken to improve the q...

The cellular immune response to respiratory syncytial virus (RSV) is important in both protection and immunopathogenesis. In contrast to HLA class I, HLA class II-restricted RSV-specific T-cell epitopes have not been identified. Here, we describe the generation and characterization of two human RSV-specific CD4(+)-T-cell clones (TCCs) associated with type 0-like cytokine profiles. TCC 1 was spe...

Plant Genetics Research Unit, United States Department of Agriculture/Agricultural Research Service, Donald Danforth Plant Science Center, 975 North Warson Street, St. Louis, Missouri 63132 (E.M.H.); University of Arkansas for Medical Sciences, Arkansas Children’s Hospital Research Institute, 1120 Marshall Street, Little Rock, Arkansas 72202 (R.M.H.); Pioneer Hi-Bred International, 7300 NW 62nd...

It is hypothesized that autoimmune diseases manifest when tolerance to self-Ags fails. One possible mechanism to break tolerance is presentation of self-Ag in an altered form. Most Ags are presented by APCs via the traditional presentation pathway that includes "epitope editing" by intracellular HLA-DM, a molecule that selects for stable MHC-peptide complexes. We were interested in testing the ...

in the North Atlantic Ocean BY SHARON KEDAR*, MICHAEL LONGUET-HIGGINS, FRANK WEBB, NICHOLAS GRAHAM, ROBERT CLAYTON AND CATHLEEN JONES Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109, USA Institute for Nonlinear Science, University of California, San Diego, La Jolla, CA 92093-0402, USA Hydrologic Research Center, San Diego, CA 92130-2069, USA Seismological Labor...