a Faculdade de Medicina S~ ao Leopoldo Mandic e Campinas, Rua Jo~ ao Lino, 914, CEP: 13450-033, Santa Barbara d’Oeste, SP, Brazil b Hospital da Santa Casa de Santa B arbara D'Oeste, Rua Jo~ ao Lino, 914, CEP: 13450-033, Santa Barbara d’Oeste, SP, Brazil c Hospital Municipal Dr. M ario Gatti, Av. Prefeito Faria Lima, 340, CEP: 13036-902, Campinas, SP, Brazil d Instituto de Anatomia Patol ogica, ...

Case Report We confirmed the Muckle-Wells syndrome phenotype of CAPS by NLRP3 genetic testing in a three generation family of Turkish Jewish origin, previously diagnosed with familial Behcet disease due to the presence of mucosal ulcers in several family members with the finding of the HLA-B51 antigen in at least one family member. Eight family members including a deceased grandfather, 4 of his...

Introduction There is an increased prevalence of Crohn’s disease (CD) in familial Mediterranean fever (FMF). Previous studies found that neither MEFV, nor NOD2/CARD15 may serve as susceptible genes, leading to FMF-CD comorbidity. In addition to NOD2/CARD15 polymorphism, ATG16L1 and IL-23R gene SNPs were also found to predispose to Crohn’s disease (CD). The role of these genes in the occurrence ...

OBJECTIVE To evaluate the safety and efficacy of ketoprofen in Transfersome® gel (IDEA-033) in comparison with a ketoprofen-free vehicle (TDT 064) for the treatment of osteoarthritis (OA) of the knee. METHODS Patients with knee OA (N = 866) were randomly assigned to receive topical IDEA-033 containing 100, 50, or 25 mg ketoprofen, or TDT 064 twice daily for 12 weeks, in a double-blind trial. ...

Joseph Amal Nathan Reactor Physics Design Division, Bhabha Atomic Research Centre, Mumbai-400085, India email:[email protected] Abstract: In this paper two conjectures are proposed based on which we can prove the first case of Fermat’s Last Theorem(FLT) for all primes p ≡ −1(mod 6). With Pollaczek’s result [1] and the conjectures the first case of FLT can be proved for all primes gr...