Activators of the CFTR Cl- channel may be useful for therapy of cystic fibrosis. Short-circuit current (Isc) measurements were done on human bronchial epithelial cells to characterize the best flavone and benzimidazolone CFTR activators identified by lead-based combinatorial synthesis and high-throughput screening. The 7,8-benzoflavone UCcf-029 was a potent activator of Cl- transport, with acti...

Case Report The patient became ill when she was 3 years old. She had fever, rash and artralgia and pericarditis. After examination in hospital she was diagnosed sJIA. She took glucocorticosteroids 1 mg/kg daily per os, methylprednisolone 10 mg/kg IV, No3, and MTX 10mg/m2/week with positive results. She took that therapy during 2 years. When the dose of GC decreased she had flares (fever, rash, ...

The coccoid cyanobacterium Chroococcidiopsis dominates microbial communities in the most extreme arid hot and cold deserts. These communities withstand constraints that result from multiple cycles of drying and wetting and/or prolonged desiccation, through mechanisms which remain poorly understood. Here we describe the first system for genetic manipulation of Chroococcidiopsis. Plasmids pDUCA7 ...

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2Mental Health Education Center, Xidian University, Xi’an, Shaanxi, China 3Department of Physical Education, Xiamen Institute of Technology, Xiamen, China 4School of Physical Education and Sport, Huaqiao University, Xiamen, China †Author for correspondence: Wenjuan Zhang, Mental Health Education Center, Xidian University, Xi’an, Shaanxi, 710126, China. Tel: +86 029-81891125, Fax: +86 029-818911...

nloaded or invasion and metastasis are major obstacles to clinical treatment that rely on cell migration. Here, cidate a mechanism of colon carcinoma cell migration that is supported by the cell surface tetraspanin (tspan8), which is known to favor tumor progression and metastasis. This mechanism is unmasked by ng of E-cadherin or its associated adapter molecule p120-catenin (p120ctn), and it i...

We present an analysis of deep XMM-Newton and Chandra observations of the z = 1.05 galaxy cluster XLSSJ022403.9-041328 (hereafter XLSSC 029), detected in the XMM-Newton large scale structure survey. Density and temperature profiles of the X-ray emitting gas were used to perform a hydrostatic mass analysis of the system. This allowed us to measure the total mass and gas fraction in the cluster a...