We report results of a VSOP (VLBI Space Observatory Programme) observation of a high redshift quasar PKS2215+020 (z = 3.57). The ∼1 milliarcsecond resolution image of the quasar reveals a prominent ‘core-jet’ structure on linear scales from 5h to 300h pc (H◦ = 100 h kms Mpc). The brightness temperatures and sizes of bright features identified in the jet are consistent with emission from relativ...

Stroke remains the number one cause of disability in the adult population. Despite scientific progress in our understanding of stroke pathology, only one treatment (tissue plasminogen activator or tPA) is able to afford benefits but to less than 3% of ischemic stroke patients. The development of experimental dietary supplement therapeutics designed to stimulate endogenous mechanisms that confer...

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Daniel S. Poon, Ehud Reich, Victoria M. Smith, Judith Kingston, M. Ashwin Reddy, John L. Hungerford, Mandeep S. Sagoo 1 Royal London Hospital, London, UK 2 Moorfields Eye Hospital, London, UK 3 St. Bartholomew’s Hospital, London, UK 4 Great Ormond Street Hospital, London, UK 5 UCL Institute of Ophthalmology, London, UK * Address for reprints: Mr Mandeep S. Sagoo, MB, PhD, FRCS (Ed), FRCOphth, M...

Case report Here we report for the first time two patients with MKD revealed by a severe neonatal colitis. Both patients had chronic bloody diarrhea and failure to thrive, one patient since the age of one month and the other twelve days. Total parenteral nutrition was required. A marked elevation of acute phase reactants was present, and no evidence of infection was found. In patient 1, ileocol...

The University of Kent at Canterbury PSSRU Cornwallis Building, University of Kent at Canterbury, Canterbury, Kent CT2 7NF Tel: 01227 823963 Fax: 01227 827038 Email: [email protected] Site Director: Professor Ann Netten The London School of Economics PSSRU London School of Economics, Houghton Street, London WC2 2AE Tel: 020 7955 6238 Fax: 020 7955 6131 Email: [email protected] Site Director: Profe...

Neurodegeneration has diverse molecular causes. α-synucleinopathies are implicated in at least three neurodegenerative diseases: Parkinson’s Disease, Dementia with Lewy bodies and Multiple System Atrophy. Age-related increases in α-synuclein and its oligomers have been observed in short-lived Nothobranchius furzeri. N. furzeri Gonarezhou, with a lifespan of 9–12 weeks, is a new model organism f...

1. UCL Respiratory, Royal Free Campus, University College London, London, UK, NW3 2PF Corresponding Author TEL: 020 783