Apelin peptide analogues displaying bias towards G protein signalling pathways have beneficial cardiovascular actions compared with the native peptide in humans in vivo. Our aim was to determine whether small molecule agonists could retain G protein bias. We have identified a biased small molecule, CMF-019, and characterised it in vitro and in vivo. In competition radioligand binding experiment...

Interpreting RG flows as dynamical systems in the space of couplings we produce a variety of constraints, global (topological) as well as local. These constraints, in turn, rule out some of the proposed RG flows and also predict new phases and fixed points, surprisingly, even in familiar theories such as O(N) model, QED3, or QCD4. ar X iv :1 60 8. 06 63 8v 1 [ he pth ] 2 3 A ug 2 01 6

the stability of ten winter safflower cultivars and lines was evaluated in three different environmental conditions in karaj, isfahan and darab in iran, a randomized complete block design with 4 replications over three years (1995, 1996 and 1997). simple analysis of variances of grain and oil yields from each experiment showed significant differences among the genotypes. after conducting a homo...

Case report 1A 72-year-old man with diagnosis of Relapsing Polychondritis and Myelodysplastic syndrome (MDS) was referred for a 4-yr history of recurrent fever (37.5 to 39°C) accompanied by sudden onset of cutaneous purple papules on the extremities and hypodermic painful nodules on the forehead and scalp. The patient suffered of autoimmune atrophic gastritis and severe metasteroidal osteoporos...

1Planetary Geosciences Institute, Department of Geological Sciences, University of Tennessee, Knoxville, Tennessee 37996-1410, USA 2Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, Kosygin St. 19, Moscow 117975, Russia 3Institute of Meteoritics, University of New Mexico, Albuquerque, New Mexico 87131, USA 4Department of Civil Engineering and Geological ...