observed that the villages or divisions of this town (Ghiniot) situate 011 the higher levels, suffer only fractionally compared with those villages or divisions of the town situated 011 the lowerlevels ; and it is also observed here and there that though a village is situated 011 a higher level, but it the people have to work on lowerlying cultivated fields, and have to depend for their water-s...

BACKGROUND Overexpression of Aurora A and B has been reported in a wide range of tumor types, including gastric cancer. Anti-angiogenesis has been considered as an important therapeutic modality in advanced gastric cancer. Here we identified a novel compound TY-011 with promising antitumor activity by targeting mitotic kinases (Aurora A and B) and angiogenic receptor tyrosine kinase (VEGFR2). ...

BACKGROUND AND PURPOSE Arachidonic acid that is released following cerebral ischemia can be metabolized to 20-hydroxyeicosatetraenoic acid (20-HETE). 20-HETE is a potent vasoconstrictor that may contribute to ischemic injury. This study examined the effects of blockading the synthesis of 20-HETE with TS-011 on infarct size after transient occlusion of the middle cerebral artery (MCAO) of rats a...

The development of routing protocols for mobile ad hoc networks is a challenging and active research area, and a variety of approaches have been developed. Among them, geographic routing strategies use knowledge of the devices’ physical positions to achieve efficient routing performance – a critical goal for networks of resource-constrained devices. Strategies have also been developed to perfor...

Sotatercept (ACE-011), a recombinant human fusion protein containing the extracellular domain of the human Activin receptor IIA, binds to and inhibits activin and other members of the transforming growth factor -β (TGF-β) superfamily. Administration of sotatercept led to a rapid and sustained increase in red blood cell (RBC) count and haemoglobin (Hb) in healthy volunteers (phase I clinical tri...

We present the results of calculations of surface relaxations, rumplings, energetics, optical band gaps, and charge distribution for the SrZrO(3) and PbZrO(3) (001) and (011) surfaces using the ab initio code CRYSTAL and a hybrid description of exchange and correlation. We consider both SrO(PbO) and ZrO(2) terminations of the (001) surface and Sr(Pb), ZrO, and O terminations of the polar SrZrO(...

PURPOSE CT-011 is a humanized IgG1 monoclonal antibody that modulates the immune response through interaction with PD-1, a protein belonging to the B7 receptor family present on lymphocytes. The objectives of this phase I study were to assess the dose-limiting toxicities, to determine the maximum tolerated dose, and to study the pharmacokinetics of CT-011 administered once to patients with adva...

Carcass growth is made up primarily of fat and protein. As cattle approach mature weight, carcass gain makes up a higher percentage of total gain. This is why dressing percentage increases with days on feed. Although performance is typically reduced for long fed cattle, adjusting performance for dressing percent can give us an indication of the performance of carcass growth. Fat makes up a high...

A new approach for epitaxial stabilisation of ferroelectric orthorhombic (o-) ZrO2 films with negative piezoelectric coefficient in ∼ 8nm thick grown by ion-beam sputtering is demonstrated. Films on (011)-Nb:SrTiO3 gave the oriented o-phase, as confirmed transmission electron microscopy and backscatter diffraction mapping, grazing incidence x-ray Raman spectroscopy. Scanning probe techniques ma...