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Introduction Pyogenic sterile Arthritis Pyoderma gangrenosum and Acne (PAPA) syndrome is a rare autosomal dominant inherited autoinflammatory disease caused by mutations in Proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1). In childhood, the syndrome is featured by recurrent sterile, erosive arthritis, potentially leading to joint destruction. By puberty, cutaneous symptoms b...
This study reflects on the range of collaborations in two distinct but thematically linked UCL research projects which consider the role of culture in health promotion: Museums on Prescription (2014–2017), in partnership with Canterbury Christ Church University, explores the value of heritage encounters in social prescribing for lonely older adults at risk of social isolation; and Not So Grim U...
Introduction The NLRs (Nucleotide-binding domain and Leucine-rich repeat containing Receptors) are a family of intracellular innate immune receptors involved in host defense. Upon activation, NLRs form large protein complexes called “inflammasomes” that bind and activate Caspase-1, resulting in proteolytic activation of the pro-inflammatory cytokines pro-IL-1b and pro-IL-18 and also induce a Ca...
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