OBJECTIVE Doxorubicin (DOX) is an effective anticancer drug but its clinical application is limited because it induces apoptosis in cardiomyocytes and leads to permanent degenerative cardiomyopathy and heart failure possibly due to oxidative stress. Recent studies showed that Capparis spinosa (C. spinose) exhibits potent antioxidant activity. So, in this study, we explored the protective effect...

In addition to being consumed as food, caper (Capparis spinosa L.) fruits are also used in folk medicine to treat inflammatory disorders, such as rheumatism. C. spinosa L. is rich in phenolic compounds, making it increasingly popular because of its components’ potential benefits to human health. We analyzed a number of individual phenolic compounds and investigated in vitro biological activitie...

The 'ethnodrug' Capparis spinosa L. has several pharmacological activities. First, it was found in previous experiments that an ethyl acetate extract of Capparis spinosa L. (CSE) exhibited antioxidant activity. In order to further research this finding, the present study investigate the blood biochemical indices, injury, energy metabolism, oxidative damage and mitochondrial membrane potential (...

background cyclophosphamide (cp) is one of the most popular alkylating anticancer drugs despite its toxic side effects, including nephrotoxicity, hematotoxicity, mutagenicity, and immunotoxicity. capparis spinosa is a multipurpose plant that contains a number of chemically active and diverse secondary metabolites, particularly flavonoids. rutin and quercetin are two major flavonoids in the cape...

objective: diabetes mellitus is the most common metabolic disorders with severe impact on quality of life. reducing serum glucose levels and normalization of serum lipid is of great clinical importance for treating diabetes. to our knowledge, there are not any evidences about the anti-diabetic action of capparis spinosa root. in the present study the effects of the c. spinosa root extract on di...

objective: doxorubicin (dox) is an effective anticancer drug but its clinical application is limited because it induces apoptosis in cardiomyocytes and leads to permanent degenerative cardiomyopathy and heart failure possibly due to oxidative stress. recent studies showed that capparis spinosa (c. spinose)exhibits potent antioxidant activity. so, in this study, we explored the protective effect...

many hepatoprotective herbal preparations have been recommended in alternative systems of medicine for the treatment of hepatic disorders. no systematic study has been done on protective efficacy of capparis spinosa (capparidaceae) to treat hepatic diseases. protective action of c. spinosa ethanolic root bark extract was evaluated in this study in an animal model of hepatotoxicity, which was in...