The ribonucleoprotein particles were isolated from livers of rats fed basal and 4-dimethylaminoazobenzene (DAB) diets, from DAB-induced primary tumors and from Novikoff hepatoma. The results showed that the protein and ribonueleic acid contents of the ribosomal fraction decreased equally in both basaland DAB-fed rats after seven weeks of feeding, and returned to normal levels after 23 weeks. Th...

DRK, the Drosophila homolog of the SH2-SH3 domain adaptor protein Grb2, is required during signaling by the sevenless receptor tyrosine kinase (SEV). One role of DRK is to provide a link between activated SEV and the Ras1 activator SOS. We have investigated the possibility that DRK performs other functions by identifying additional DRK-binding proteins. We show that the phosphotyrosine-binding ...

To study the influence of activation of metabolic function of carcinogen to chemical carcinogenesis, effect of barbital, an inducer of enzymes related to drug metabolism, was studied on the development of liver cancer in the rat fed with 4-dimethylaminoazobenzene (DAB), and compared with that of 3-methylcholanthrene,*4 known to antagonize the carcinogenic effect of DAB. In an animal experiment ...

Shortly after Hitler’s rise to power, the Prussian State Library was restructured, birthing a new entity – Deutsch-Ausländischer Buchtausch (DAB, German Foreign Book Exchange). The DAB responsible for exchanging books and serials with scholarly institutions worldwide. In 1936, University of Denver (DU) received gift from DAB. Nearly 50 per cent would be categorised as Nazi propaganda or eugenic...

The reactions of the tetraphosphine ligand DAB-G0-(PPh2)4 (DAB = 1,4-diaminobutane; G0 = Generation 0) or the octaphosphine ligand DAB-G1-(PPh2)8 (G1 = Generation 1) with the gold precursor [AuCl(tht)] (tht =tetrahydrothiophene) and the corresponding 4-substituted benzenethiolate lead to the (phosphine)gold(I) thiolate complexes [Au4(S-C6H4-X)4[(DAB-G0-(PPh2)4]] (X = F (11), MeO (12), Me (13) a...

BACKGROUND This study was carried out to isolate and characterize the bacterial strains from lindane-contaminated soil and they were also assessed for their lindane-degrading potential. METHODS In this study the enrichment culture method was used for isolation of  lindane degrading bacterial isolates, in which the mineral salt medium (MSM) supplemented with different concentrations of lindane...

We suggest a novel approach to enhancing antimicrobial drug action by utilizing engineered peptide conjugates. Our most potent conjugates, [fMLF]PMBN and [fMLF]PMEN, are nonapeptides derived from polymyxin B's (PMB's) cyclic moiety (Thr-Dab-cyclo[Dab-Dab-d-Phe-Leu-Dab-Dab-Thr], where Dab is 2,4-diaminobutyric acid) and polymyxin E's (PME's) cyclic moiety (Thr-Dab-cyclo[Dab-Dab-d-Leu-Leu-Dab-Dab...

Cultured rat liver cells which were cloned from a single cell were transformed into malignant cells by a chemical carcinogen, 4-dimethylaminoazobenzene (DAB). The DAB-transformed cells produced tumors when back-transplanted into new-born rats but the carcinogen-untreated control cells did not. Characteristics of the transformed liver cells were compared to those of DABuntreated control cells in...

DAB-Am64-(1B4M-Gd)(64) is a newly synthesized macromolecular liver magnetic resonance imaging (MRI) contrast agent with a polypropylenimine diaminobutane (DAB) dendrimer conjugated with a bifunctional diethylenetriaminepentaacetic acid (DTPA) derivative for complexing Gd(III) atoms. The characteristics of DAB-Am64-(1B4M-Gd)(64), which quickly accumulated in the liver, have been reported recentl...