A newly diagnosed diabetic patient, recently started on chlorpropamide, required emergency admission because of sudden onset of weakness and syncope. In vitro testing confirmed the diagnosis of chlorpropamide induced haemolysis, and withdrawal of the drug resulted in clinical recovery.

A selective and sensitive gas chromatographic technique was used to measure the steady-state serum concentrations of tolbutamide and chlorpropamide in 97 patients with maturity-onset diabetes mellitus who had been taking these drugs (37 tolbutamide, 60 chlorpropamide) for at least a year. No other antidiabetic agents had been given. The serum tolbutamide concentrations varied widely between the...

The current work focuses on the development and validation of a UV spectrophotometric technique for determining chlorpropamide in bulk formulation. According to ICH criteria, method was validated number parameters, including linearity, precision, accuracy, sensitivity, limit detection (LOD), quantification (LOQ). maximum wavelength discovered be 580 nm, colorimetric created quantitative estimat...

It has been suggested previously that chlorpropamide and other hypoglycemic sulfonylureas interfere with hepatic triglyceride breakdown. Since ketogenesis from endogenous hepatic lipid stores is a measure of hepatic triglyceride hydrolysis, ketogenesis derived from endogenous lipids as well as ketogenesis derived from exogenously added isotopic oleate was determined in isolated hepatocytes from...

Chlorpropamide-alcohol flushing may be due to sensitivity to endogenous opiates. To investigate this possibility the plasma met-enkephalin and beta-endorphin responses to sherry with and without chlorpropamide were studied in six patients with non-insulin dependent diabetes and in six normal subjects. After chlorpropamide all patients showed a rise in met-enkephalin concentrations from a basal ...

Response of antidiuretic hormone to chlorpropamide Chlorpropamide has been used to treat diabetes insipidus since 1966,1 but its mode of action is still not entirely clear. There is good agreement that it augments the renal effects of endogenous antidiuretic hormone,2 but it might also cause pituitary release.3 To help clarify this we have measured serial plasma concentrations of antidiuretic h...

This study was performed to assess the effect of chlorpropamide therapy on the fibrinolytic activity of blood of maturity onset diabetics. Normal controls were also studied and the results compared with diabetics. Diabetics were found to have deficient fibrinolytic activity compared with non-diabetics but chlorpropamide did not appear significantly to affect this deficiency either in males or f...

LITTLE information as yet is obtainable on the reliability of the pre-treatment glucose tolerance test as an indication of subsequent control of diabetes on chlorpropamide. Agreement on other indications of likely success (age of onset of diabetes over 40 years, absence of previous ketosis, relative stability, etc.) has been reached in numerous papers (Murray, et al. (1958), Hills and Abelove (...