The biphasic pattern of glucose-induced insulin secretion is altered in type 2 diabetes. Impairment of the first phase is an early sign of β-cell dysfunction, but the underlying mechanisms are still unknown. Their identification through in vitro comparisons of islets from diabetic and control subjects requires characterization and quantification of the dynamics of insulin secretion by normal is...

Graphene nanoplatelets (GNP) are used to produce wood plastic composites (WPC) with improved electrical and thermal conductivity. The polypropylene/wood/GNP hybrid produced by melt compounding followed hot pressing. effect of GNP loadings (5, 10 15 wt%) on conductivity, tensile properties, degradation WPC containing 20 wt% flour is studied. fast slow cooling rates during pressing the surface re...

Understanding transportation and deposition (TD) of aerosol particles in the human respiratory system can help clinical treatment lung diseases using medicines. The airway diameters breathing capacity lungs normally increase with age until 30. Many studies have analyzed particle TD airways. However, knowledge nanoparticle airways infants children varying inhalation flow rates is still limited l...

Glycerol monolaurate (GML), a representative fatty acid glyceride, was used to promote growth. This study investigated the effects of GML in diets on growth, serum biochemical parameters, antioxidant capacity, liver morphology and lipid metabolism for juvenile pompano Trachinotus ovatus . Six groups T. (mean weight = 14.00 ± 0.70 g) were fed with six diets, containing varying levels 0.00% (G0),...

We previously showed that after seven generations of artificial selection of rats for running capacity, maximal O2 uptake (VO2max) was 12% greater in high-capacity (HCR) than in low-capacity runners (LCR). This difference was due exclusively to a greater O2 uptake and utilization by skeletal muscle of HCR, without differences between lines in convective O2 delivery to muscle by the cardiopulmon...

Untrained rats selectively bred for either high (HCR) or low (LCR) treadmill running capacity previously demonstrated divergent physiological traits as early as the seventh generation (G7). We asked whether continued selective breeding to generation 15 (G15) would further increase the divergence in skeletal muscle capillarity, morphometry, and oxidative capacity seen previously at G7. At G15, m...

Excessive accumulation of intracellular calcium is the most critical step after spinal cord injury (SCI). Reducing the calcium influx should result in a better recovery from SCI. Calcium channel blockers have been shown a great potential in reducing brain and spinal cord injury. In this study, we first tested the neuroprotective effect of MVIIC on slices of spinal cord subjected to ischemia eva...