Three MHC class II-derived synthetic peptides (I-A beta (g7)1-16, I-A beta (g7)52-77 and I-A alpha (g7)63-82YC) were analyzed for their ability to bind to syngeneic and allogeneic MHC class II molecules using a whole cell, competitive peptide binding assay. These studies demonstrated that the A beta (g7)1-16 peptide was able to specifically bind to syngeneic as well as to four allogeneic MHC cl...

OBJECTIVES To locate the acquired antibiotic resistance genes, including the amikacin resistance transposon TnaphA6, in the genome of an Australian isolate belonging to Acinetobacter baumannii global clone 1 (GC1). METHODS A multiply antibiotic-resistant GC1 isolate harbouring TnaphA6 was sequenced using Illumina HiSeq, and reads were used to generate a de novo assembly and determine multiloc...

An agar-degrading bacterium, designated as strain G7(T), was isolated from a coastal seawater sample from Gaya Island (Gayado in Korean), Republic of Korea. The isolated strain G7(T) is gram-negative, rod shaped, aerobic, non-motile, and non-pigmented. A similarity search based on its 16S rRNA gene sequence revealed that it shares 95.5%, 90.6%, and 90.0% similarity with the 16S rRNA gene sequen...

Type 1 diabetes is an autoimmune disease mediated by beta cell-specific CD4(+) and CD8(+) T cells. Tracking beta cell-specific T cells is one approach to monitor the diabetogenic response in at risk or diabetic individuals. Such analyses, however, are limited to PBL because T cells infiltrating the pancreatic islets are normally inaccessible. A key issue is whether peripheral beta cell-specific...

سابقه و هدف: امروزه با گسترش فعالیت واحدهای صنعتی، غلظت آلاینده­ ها در هوا افزایش یافته انسان­ از طریق تنفس، بلعیدن جذب پوستی معرض آن­ها قرار می­ گیرند. میان تمام آلاینده ­ها، فلزات سنگین به دلیل ماهیت سمی خود بسیار مورد توجه متخصصان زیست ­محیطی گرفته ­اند. بالای محیط ­زیست، می ­تواند خطر اثرات نامطلوب بر سلامتی انسان را دهد. شهرک صنعتی ناجی زنجان ریخته ­گری مس آلیاژهای آن، ­عنوان یکی منابع انت...

Rsv1, a single dominant resistance gene in soybean PI 96983 (Rsv1), confers extreme resistance against all known American strains of Soybean mosaic virus (SMV), except G7 and G7d. SMV-G7 provokes a lethal systemic hypersensitive response (LSHR), whereas SMV-G7d, an experimentally evolved variant of SMV-G7, induces systemic mosaic. To identify the elicitor of Rsv1-mediated LSHR, chimeras were co...

There are seven pathotypes of soybean mosaic virus (SMV) representing seven strain groups (G1-G7) in the United States. Soybean genotypes [Glycine max (L.) Merr.] may exhibit resistant (R), susceptible (S), or necrotic (N) reactions upon interacting with different SMV strains. This research was conducted to investigate whether reactions to two SMV strains are controlled by the same gene or by s...

تمام ترکیبات اورانیم، سمی و رادیواکتیو هستند. بودن این عنصر می‌تواند کشنده باشد. با توجه به سمیت شیمیایی رادیواکتیویته ضروری است از ورود آن طبیعت جلوگیری شود. پسماندهای خروجی مراکز صنعتی- هسته­ای نیز دارای مقادیر مختلفی اورانیم می­باشد لذا حذف پساب اهمیت ویژه­ای برخوردار است. سویی دیگر، نظر محدودیت منابع آن، بازیابی پسماندها، ارزش اقتصادی می­باشد. در پژوهش حاضر، روش سطح پاسخ (RSM) بر اساس طرح م...

OBJECTIVES Patients with rheumatoid arthritis (RA) have a reduced life expectancy due to increased cardiovascular disease. The lack of a suitable animal model resembling both RA and atherosclerosis has hindered studies demonstrating a direct link between systemic inflammation in RA and the development of atherosclerosis. Our objective was to overcome this barrier by generating an animal model (...