BACKGROUND Kala-azar is a multisystem infection of the reticuloendothelial system. Various hematologic abnormalities have been described in kala-azar including hemophagocytic syndrome (HPS).  METHODS We reviewed bone marrow aspirate smears from 18 documented cases of kala-azar complicated by HPS.  RESULTS The bone marrow smears were hypercellular with erythroid hyperplasia. Megaloblastic ch...

The preliminary results of treatment of 50 cases of kala-azar and 2 cases of post-kala-azar dermal leishmaniasis were reported by the writers (Sen Gupta and Chakravarty, 1945) last year. Of the 50 cases of kala-azar treated, two died during treatment and 48 were discharged as clinically cured. The immediate results of this trial were quite satisfactory, the immediate cure rate being about 96 pe...

Enteric fever(l) and Kala-azar (vis-ceral leishmaniasis) are endemic, in and around Patna. Kala-azar usually has an indolent course but it can present as an acute disease with fever, anorexia and vomiting(2,3). At times both the diseases are so closely similar in their presentation , that differential diagnosis is not always clear, Widal test, inspite of its limitations and fallacies is still w...

11 Summary Despite the fact that anemia is one of the most striking clinical features of visceral leishmaniasis (kala-azar), the factors involved in the pathogenesis are not fully understood. The cause of anemia seen in these patients is often multifactorial including sequestration and destruction of the erythrocytes in the enlarged spleen, hemophagocytosis and alterations in erythrocyte membra...

Post-kala-azar dermal leishmaniasis (PKDL) occurs after kala-azar treatment and acts as a durable infection reservoir. On the basis of active case finding among 22,699 respondents, 813 (3.6%) had had kala-azar since 2002, of whom 79 (9.7%) developed PKDL. Eight additional patients with PKDL had no history of kala-azar. Annual kala-azar incidence peaked at 85 cases per 10,000 person-years in 200...

For efficient gene delivery into cells, a new formulation method based on using polyethylene glycol (PEG) grafted poly(L-lysine) (PLL) and a fusogenic peptide is presented in this study. First, PEG grafted PLL (PEG-g-PLL) was complexed with DNA by controlling the polymer/DNA ratio to form negatively charged nano-particulate complexes. A positively charged fusogenic peptide, KALA, was then coate...

In the Indian Medical Gazette for June 1927, Chopra, Gupta, and David described a new serum test for kala-azar. These workers observed that when certain organic compounds of antimony were brought in contact with the serum from kala-azar patients in a miniature testtube, a thick flocculent precipitate was formed at the junction of the two; whereas with nonkala-azar sera no such precipitation occ...

BACKGROUND Visceral Leishmaniasis, commonly known as kala-azar, is widely prevalent in Bihar. The National Kala-azar Control Program has applied house-to-house survey approach several times for estimating Kala-azar incidence in the past. However, this approach includes huge logistics and operational cost, as occurrence of kala-azar is clustered in nature. The present study aims to compare effic...

Malaria complicating kala-azar That malaria may complicate kala-azar was recognized by the early workers on kala-azar in this country. Napier (1927) remarked that plasmodial and leishmanial infection must copyist in t.^e same r^fip-nt verv froouent.lv. but the occasions on which both parasites would be found in the same film of either peripheral blood or spleen puncture material were few. Malar...

Kala-azar has re-emerged from near eradication. The annual estimate for the incidence and prevalence of kala-azar cases worldwide is 0.5 million and 2.5 million, respectively. Of these, 90% of the confirmed cases occur in India, Nepal, Bangladesh and Sudan. In India, it is a serious problem in Bihar, West Bengal and eastern Uttar Pradesh where there is under-reporting of kala-azar and post kala...