نتایج جستجو برای: ژن ship2

تعداد نتایج: 15922  

Journal: :The Biochemical journal 2003
Sylvie Giuriato Xavier Pesesse Stéphane Bodin Takehiko Sasaki Cécile Viala Evelyne Marion Joseph Penninger Stéphane Schurmans Christophe Erneux Bernard Payrastre

Src homology domain 2-containing inositol 5-phosphatases 1 and 2 (SHIP1 and SHIP2) are capable of dephosphorylating the second messenger PtdIns(3,4,5) P3 (phosphatidylinositol 3,4,5-trisphosphate) and interacting with several signalling proteins. SHIP1 is essentially expressed in haematopoietic cells, whereas SHIP2, a closely related enzyme, is ubiquitous. In the present study, we show that SHI...

Journal: :International journal of clinical and experimental pathology 2013
Maoying Fu Xuefeng Gu Huihui Ni Wei Zhang Feng Chang Li Gong Xiaoxiao Chen Jiang Li Liang Qiu Chuanbing Shi Jun Bao

Inositol polyphosphate phosphatase-like 1 (INPPL1), also known as SH2-containing inositol 5'-phosphatase 2 (SHIP2), has been suggested to act downstream of the PI3K/AKT pathway and play an important function in tumor development and progression. However, the associations between SHIP2 expression and the clinical features to determine its clinicopathologic significance in hepatocellular carcinom...

2014
Ju Yang Maoying Fu Yaoguang Ding Yajing Weng Weifei Fan Xiaolin Pu Zhijun Ge Feng Zhan Huihui Ni Wei Zhang Feng Jin Ning Xu Jiang Li Liang Qiu Jun Wang Xuefeng Gu

SH2-containing inositol 5'-phosphatase 2 (SHIP2), which generally regulates insulin signaling, cytoskeleton remodeling, and receptor endocytosis, has been suggested to play a significant role in tumor development and progression. However, the associations between SHIP2 expression and the clinical features to evaluate its clinicopathologic significance in colorectal cancer (CRC) have not been de...

2012
Stephen J. Mills Camilla Persson Gyles Cozier Mark P. Thomas Lionel Trésaugues Christophe Erneux Andrew M. Riley Pär Nordlund Barry V. L. Potter

Phosphoinositides regulate many cellular processes, and cellular levels are controlled by kinases and phosphatases. SHIP2 (SH2 (Src homology 2)-domain-containing inositol-phosphatase-2) plays a critical role in phosphoinositide signaling, cleaving the 5-phosphate from phosphatidylinositol 3,4,5-trisphosphate. SHIP2 is thought to be involved in type-2 diabetes and obesity, conditions that could ...

Journal: :Journal of virology 2011
Shannon McNulty Kimberly Powell Christophe Erneux Daniel Kalman

After fusing with the plasma membrane, enveloped poxvirus virions form actin-filled membranous protrusions, called tails, beneath themselves and move toward adjacent uninfected cells. While much is known about the host and viral proteins that mediate formation of actin tails, much less is known about the factors controlling release. We found that the phosphoinositide 5-phosphatase SHIP2 localiz...

Journal: :Neuroscience 2001
E Muraille D Dassesse J M Vanderwinden H Cremer B Rogister C Erneux S N Schiffmann

The germinative ventricular zone of embryonic brain contains neural lineage progenitor cells that give rise to neurons, astrocytes and oligodendrocytes. The ability to generate neurons persists at adulthood in restricted brain areas. During development, many growth factors exert their effects by interacting with tyrosine kinase receptors and activate the phosphatidylinositol 3-kinase and the Ra...

1999
David Wisniewski Annabel Strife Steve Swendeman Hediye Erdjument-Bromage Scott Geromanos W. Michael Kavanaugh Paul Tempst Bayard Clarkson

Because of the probable causal relationship between constitutive p210bcr/abl protein tyrosine kinase activity and manifestations of chronic-phase chronic myelogenous leukemia (CML; myeloid expansion), a key goal is to identify relevant p210 substrates in primary chronic-phase CML hematopoietic progenitor cells. We describe here the purification and mass spectrometric identification of a 155-kD ...

2013
Aline Awad Sokhavuth Sar Ronan Barré Clotilde Cariven Mickael Marin Jean Pierre Salles Christophe Erneux Didier Samuel Ama Gassama-Diagne

The main targets of hepatitis C virus (HCV) are hepatocytes, the highly polarized cells of the liver, and all the steps of its life cycle are tightly dependent on host lipid metabolism. The interplay between polarity and lipid metabolism in HCV infection has been poorly investigated. Signaling lipids, such as phosphoinositides (PIs), play a vital role in polarity, which depends on the distribut...

2016
Charles V Rajadurai Serhiy Havrylov Paula P Coelho Colin D H Ratcliffe Kossay Zaoui Bruce H Huang Anie Monast Naila Chughtai Veena Sangwan Frank B Gertler Peter M Siegel Morag Park

Invadopodia are specialized membrane protrusions that support degradation of extracellular matrix (ECM) by cancer cells, allowing invasion and metastatic spread. Although early stages of invadopodia assembly have been elucidated, little is known about maturation of invadopodia into structures competent for ECM proteolysis. The localized conversion of phosphatidylinositol(3,4,5)-triphosphate and...

2016
Elmer Hoekstra Asha M. Das Marcella Willemsen Marloes Swets Peter J.K. Kuppen Christien J. van der Woude Marco J. Bruno Jigisha P. Shah Timo L.M. ten Hagen John D. Chisholm William G. Kerr Maikel P. Peppelenbosch Gwenny M. Fuhler

Colorectal cancer (CRC) is the second most common cause of cancer-related death, encouraging the search for novel therapeutic targets affecting tumor cell proliferation and migration. These cellular processes are under tight control of two opposing groups of enzymes; kinases and phosphatases. Aberrant activity of kinases is observed in many forms of cancer and as phosphatases counteract such "o...

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