نتایج جستجو برای: ژن magi2
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Genomic imprinting characterizes genes with a monoallelic expression, which is dependent on the parental origin of each allele. Approximately 150 imprinted genes are known to date, in humans and mice but, though computational searches have tried to extract intrinsic characteristics of these genes to identify new ones, the existing list is probably far from being comprehensive. We used a high-th...
Exome sequencing has revealed that somatic mutations in human melanomas greatly exceed those in other cancers, making it a challenge for predicting causative genes from the large collection of mutations. Here we used low‐copy piggyBac (PB) transposon mutagenesis in mice with conditionally activated Braf in melanocytes to screen for genes promoting melanoma development. Analysis of eleven PB‐ind...
The Wilms' tumor suppressor gene 1 (WT1) encodes a zinc finger transcription factor. Mutation of WT1 in humans leads to Wilms' tumor, a pediatric kidney tumor, or other kidney diseases, such as Denys-Drash and Frasier syndromes. We showed previously that inactivation of WT1 in podocytes of adult mice results in proteinuria, foot process effacement, and glomerulosclerosis. However, the WT1-depen...
BACKGROUND Inflammatory bowel disease (IBD) is associated with increased intestinal permeability, which involves paracellular passage regulated through tight junctions (TJ). The aim of the study was to investigate single nucleotide polymorphisms (SNP) located in genes encoding interacting TJ proteins and corresponding expressions, in relation to IBD. METHODS Allelic associations between TJ-re...
Introduction Long non-coding RNA Membrane-Associated Guanylate Kinase Inverted 2 Antisense 3 (MAGI2-AS3) has been identified as a predictive characteristic for prostate cancer (PC). However, the underlying mechanism of MAGI2-AS3 in PC is yet unclear. Material and methods The gene expression was detected via reverse transcription quantitative PCR. Cell viability, apoptosis invasion were cell cou...
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