نتایج جستجو برای: ژن kras
تعداد نتایج: 23037 فیلتر نتایج به سال:
Background: Endometriosis is one of the most common benign gynecological diseases which is characterized by endometriallike tissue growing outside the uterine cavity. Although the pathology of endometriosis remains unknown, the genetic predisposition plays an apparent role. Several genes have been contributed to endometriosis, but it seems KRAS has a crucial role, because its activation results...
Liquid biopsy (LB) is a feasible tool able to detect genomic alterations in cancer at baseline and also as longitudinal monitoring identify resistance mutations. In patients (pts) with mNSCLC, when tissue remains difficult procedure, LB might be crucial for therapeutical options, especially the immunotherapy (IO) target therapy era. The aim of this bicentric study assess prognostic value mNSCLC...
Rationale KRAS is the most common and, simultaneously, the most ambiguous oncogene implicated in human cancer. Despite KRAS mutations were identified in Non Small Cell Lung Cancers (NSCLCs) more than 20 years ago, selective and specific inhibitors aimed at directly abrogating KRAS activity are not yet available. Nevertheless, many therapeutic approaches have been developed potentially useful to...
aim : the aim of the current investigation was to examine the profile of kras mutations accompanied with msi (microsattelite instability) status in polyps and colorectal carcinoma tissues in an iranian population. background : kras mutations in colorectal cancer cause resistance to anti-epidermal growth factor receptor (egfr). so it can be considered as a true indicator of egfr pathway activati...
تخمدان به شکل دو غده کوچک در دو سوی جسم رحم قرار گرفته که توسط انتهای لوله تخمدان پوشانده شده اند. سرطان اپی تلیال تخمدان رایج ترین نوع این سرطان بوده و تا هنگام متاستاز معمولاً بدون علامت باقی می ماند. به همین دلیل در بین همه بدخیمی های دستگاه تناسلی زنان، از بالاترین موارد مرگ و میر برخوردار است. این سرطان، ششمین سرطان زنان در کشورهای غربی و پنجمین علت مرگ به دلیل سرطان در زنان ایالات متحده آم...
Genetic lesions that activate KRAS account for ∼30% of the 1.6 million annual cases of lung cancer. Despite clinical need, KRAS is still undruggable using traditional small-molecule drugs/inhibitors. When oncogenic Kras is suppressed by RNA interference, tumors initially regress but eventually recur and proliferate despite suppression of Kras Here, we show that tumor cells can survive knockout ...
knowledge about the clinical significance of v-raf murine sarcoma viral oncogene homolog b1 ( braf ) mutations in colorectal cancer (crc) is growing. braf encodes a protein kinase involved with intracellular signaling and cell division. the gene product is a downstream effector of kirsten ras 1( kras ) within the ras/raf/mapk cellular signaling pathway. evidence suggests that braf mutations, li...
We performed this retrospective study to investigate whether the KRAS mutation status and its subtypes could predict the effect of first-line platinum-based chemotherapy in Chinese patients with non-small cell lung cancer (NSCLC). Patients received who had KRAS mutations were enrolled. Correlations between KRAS mutations, specific mutant subtypes and responses to chemotherapy were analyzed usin...
The recent interest to modulate autophagy in cancer therapy has been hampered by the dual roles of this conserved catabolic process in cancer, highlighting the need for tailored approaches. Since RAS isoforms have been implicated in autophagy regulation and mutation of the KRAS oncogene is highly frequent in colorectal cancer (CRC), we questioned whether/how mutant KRAS alleles regulate autopha...
CTEN/TNS4 is an oncogene in colorectal cancer (CRC) which enhances cell motility although the mechanism of Cten regulation is unknown. We found an association between high Cten expression and KRAS/BRAF mutation in a series of CRC cell lines (p = 0.03) and hypothesised that Kras may regulate Cten. To test this, Kras was knocked-down (using small interfering (si)RNA) in CRC cell lines SW620 and D...
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