250 Word Limit) Objective: Interleukin-1 beta (IL1β) is a pro-inflammatory cytokine that mediates arthritic pathologies. Our objective was to evaluate pain and limb dysfunction resulting from IL1β overexpression in the rat knee and investigate the ability of local IL1 receptor antagonist (IL1Ra) delivery to reverse associated pathology. Design: IL1β over-expression was induced in the right knee...

BACKGROUND Interleukin 1 (IL1) plays an important role in the physiology of human endometrium and is recognized as a major and early embryonic signal. Tight control over the local endometrial action of this cytokine is critical for normal reproductive functions. The coordinated regulation of IL1 receptors types I and II (IL1R1 and IL1R2) and IL1 receptor antagonist (IL1RA) in endometrial cells ...

Plasmid encoded protein (Pet), a product of E. coli, infiltrates leukocyte in experimental models and acts on macrophages as a chemokine. As an immune response orchestrator, macrophages play an important role in inducing proinflammatory cytokines. In this work, we tested whether in macrophages Pet stimulates the expression of IL1, TNF , MIF and the antagonist IL1Ra. We also sought the IKK /NF B...

Schizas, N. 2015. Neuroprotection in the Injured Spinal Cord. Novel Strategies using Immunomodulation, Stem cell Transplantation and Hyaluronic acid Hydrogel carriers. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1106. 59 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9255-7. The overall aim of this thesis was to establish strategies to min...

OBJECTIVE To investigate changes in the levels of circulating cytokines with a focus on the Th1/Th2 balance during and after pregnancy in patients with rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), and ankylosing spondylitis (AS). METHODS Plasma and serum samples of 34 pregnant patients, 19 with RA, 6 with JIA, and 9 with AS, and of 30 healthy pregnant women, 20 non-pregnant...

Chronic arthritis is characterised by chronic joint inflammation and concurrent joint erosion and destruction. The inflammatory cytokine interleukin 1 (IL1) has been shown to be a key mediator in the autoimmune disease rheumatoid arthritis (RA). Interleukin 1 mediates bone resorption and cartilage destruction, but may not play as dominant a part in joint swelling and inflammation. Interleukin 1...

Previous results have demonstrated that anti-D therapy in children with chronic auto-immune thrombocytopenic purpura (AITP) induced a significant increase in several pro- and anti-inflammatory plasma cytokines within 2 hours of administration. To investigate the biologic basis of these early in vivo responses, we developed a flow cytometric assay to measure Fc-dependent responses of human perip...

BACKGROUND An association has been described between mortality in children with meningococcal disease and functional polymorphisms in the interleukin-1 (IL1) cluster. We undertook a multicenter study to evaluate associations of these polymorphisms in a Central European population. PATIENTS AND METHODS The study involved 95 Middle European pediatric hospitals. We collected blood samples from, ...

The induction of heme oxygenase-1 (HO-1; Hmox1) by inflammation, for instance in sepsis, is associated both with an anti-inflammatory response and with mitochondrial biogenesis. Here, we tested the idea that HO-1, acting through the Nfe2l2 (Nrf2) transcription factor, links anti-inflammatory cytokine expression to activation of mitochondrial biogenesis. HO-1 induction after LPS stimulated anti-...