نتایج جستجو برای: ژن catsper

تعداد نتایج: 15936  

2016
Shameem Sultana Syeda Erick J. Carlson Melissa R. Miller Rawle Francis David E. Clapham Polina V. Lishko Jon E. Hawkinson Derek Hook Gunda I. Georg

The basal fungus Allomyces macrogynus (A. macrogynus) produces motile male gametes displaying well-studied chemotaxis toward their female counterparts. This chemotaxis is driven by sirenin, a sexual pheromone released by the female gametes. The pheromone evokes a large calcium influx in the motile gametes, which could proceed through the cation channel of sperm (CatSper) complex. Herein, we rep...

Journal: :Reproductive biology and endocrinology : RB&E 2003
Anna Lobley Valerie Pierron Lindsey Reynolds Liz Allen David Michalovich

BACKGROUND CatSper1 and CatSper2 are two recently identified channel-like proteins, which show sperm specific expression patterns. Through targeted mutagenesis in the mouse, CatSper1 has been shown to be required for fertility, sperm motility and for cAMP induced Ca2+ current in sperm. Both channels resemble a single pore forming repeat from a four repeat voltage dependent Ca2+ /Na+ channel. Ho...

Journal: :PLoS ONE 2008
Xinjiang Cai David E. Clapham

The mammalian CatSper ion channel family consists of four sperm-specific voltage-gated Ca2+ channels that are crucial for sperm hyperactivation and male fertility. All four CatSper subunits are believed to assemble into a heteromultimeric channel complex, together with an auxiliary subunit, CatSperbeta. Here, we report a comprehensive comparative genomics study and evolutionary analysis of CatS...

2015
Yoku Kato

they suggested that human CatSper mutations with infertility phenotype are quite rare because the patient must have homozygous mutations (the identical mutation in both alleles) for CatSper-less phenotype. Therefore, they only have seen two patients like this. The patient from PNAS paper had homozygous microdeletion in chromosome 15 which also affected CatSper2 gene, two of his brothers had the...

Journal: :The Journal of Cell Biology 2001
William A. Wells

putative calcium channel specific to sperm tails may be the best target yet for a male contraceptive. The protein, dubbed CatSper, was discovered in a homology search by David Clapham and colleagues of Harvard Medical School, Boston, MA. CatSper looks like a calcium channel, although Clapham could not detect a calcium current in transfected cells, probably because another component of the chann...

Journal: :The EMBO journal 2012
Christoph Brenker Normann Goodwin Ingo Weyand Nachiket D Kashikar Masahiro Naruse Miriam Krähling Astrid Müller U Benjamin Kaupp Timo Strünker

The sperm-specific CatSper channel controls the intracellular Ca(2+) concentration ([Ca(2+)](i)) and, thereby, the swimming behaviour of sperm. In humans, CatSper is directly activated by progesterone and prostaglandins-female factors that stimulate Ca(2+) influx. Other factors including neurotransmitters, chemokines, and odorants also affect sperm function by changing [Ca(2+)](i). Several liga...

2013
Xu-Hui Zeng Betsy Navarro Xiao-Ming Xia David E. Clapham Christopher J. Lingle

During passage through the female reproductive tract, mammalian sperm undergo a maturation process termed capacitation that renders sperm competent to produce fertilization. Capacitation involves a sequence of changes in biochemical and electrical properties, the onset of a hyperactivated swimming behavior, and development of the ability to undergo successful fusion and penetration with an egg....

2011
Chengyi Song Bo Gao Han Wu Yuxiu Xie Xiaoyan Wang Bichun Li Guohong Chen Jiude Mao

BACKGROUND Sperm ion channel proteins (CatSpers) are essential for sperm hyperactivated motility, and then penetration through the zona pellucida. The CatSper class of proteins have well been characterized in the mouse and human. However, such data for pigs are not available. In the present study, we cloned the porcine CatSper 1-4 genes, analysed their spatial expression in various organs and t...

2015
Do Rim Kim Hyu Young Kim Ha Young Kim Mun Seog Chang Seong Kyu Park

Genetic defects during spermatogenesis can lead to a reduction in sperm motility and cause male infertility. The cation channels of sperm (CatSper) play a role in the regulation of hyperactivated sperm motility in mouse testes. The effect of Trigonellae Semen (TS) on the male reproductive system and CatSper protein in mouse testes during spermatogenesis was examined. C57BL/c mice were divided i...

2015
Hannah L. Williams Steven Mansell Wardah Alasmari Sean G. Brown Stuart M. Wilson Keith A. Sutton Melissa R. Miller Polina V. Lishko Christopher L.R. Barratt Steven J. Publicover Sarah Martins da Silva

STUDY QUESTION Are significant abnormalities of CatSper function present in IVF patients with normal sperm concentration and motility and if so what is their functional significance for fertilization success? SUMMARY ANSWER Sperm with a near absence of CatSper current failed to respond to activation of CatSper by progesterone and there was fertilization failure at IVF. WHAT IS KNOWN ALREADY...

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