نتایج جستجو برای: ژنهای پپتید سنتتاز nrpss
تعداد نتایج: 2215 فیلتر نتایج به سال:
Non-ribosomal peptide synthetases (NRPSs) are enzymes that catalyze ribosome-independent production of small peptides, most of which are bioactive. NRPSs act as peptide assembly lines where individual, often interconnected modules each incorporate a specific amino acid into the nascent chain. The modules themselves consist of several domains that function in the activation, modification and con...
زمینه و اهداف: سرطان پروستات از علل شایع مرگ و میر در مردان می باشد. مطالعات نشان داده است که پپتیدهای هدف گیری کننده ی سلولهای سرطان قابلیت استفاده به عنوان ابزارهای درمانی و تشخیصی را دارند. در سالهای اخیر کتابخانه های نمایش فاژی پپتیدی برای شناسایی پپتیدهای هدف گیری کننده ی سلولهای سرطانی مختلفی بکار گرفته شده اند. هدف از این تحقیق جداسازی پپتید های هدف گیری کننده ی سلولهای آدنوکارسینومای پر...
SUMMARY Non-ribosomal peptide synthetases (NRPSs) are multi-modular enzymes, which biosynthesize many important peptide compounds produced by bacteria and fungi. Some studies have revealed that an individual domain within the NRPSs shows significant substrate selectivity. The discovery and characterization of non-ribosomal peptides are of great interest for the biotechnological industries. We h...
Nonribosomal peptides (NRPs) and polyketides (PKs) are ecologically important secondary metabolites produced by bacteria and fungi using multidomain enzymes called nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs), respectively. Previous phylogenetic analyses of fungal NRPSs and PKSs have suggested that a few of these genes were acquired by fungi via horizontal gene trans...
این تحقیق با هدف تشخیص ژنهای خاصی که مکانیسم تنش خشکی را در کنترل خود دارند صورت گرفته است. بدین منظور، تجزیه و تحلیل اطلاعات est کتابخانه گیاهان گندم، برنج، پنبه و فستوکای تحت تنش خشکی انجام شد. و در نهایت مقایسه ای بین ژن های درگیر در تنش خشکی و گروههای کارکردی کتابخانه ها انجام شد. بیان بالایی از یک ژن ناشناخته در کتابخانه برنج تحت تنش خشکی مشاهده شد. به دلیل عملکرد و ساختار ناشناخته این پرو...
Lipopeptide biosurfactants (LPBSs) consist of a hydrophobic fatty acid portion linked to a hydrophilic peptide chain in the molecule. With their complex and diverse structures, LPBSs exhibit various biological activities including surface activity as well as anti-cellular and anti-enzymatic activities. LPBSs are also involved in multi-cellular behaviors such as swarming motility and biofilm for...
Nonribosomal peptides (NRPs) are produced by NRP synthetase (NRPS) enzymes that function as molecular assembly lines. The modular architecture of NRPSs suggests that a domain responsible for activating a building block could be replaced with a domain from a foreign NRPS to create a chimeric assembly line that produces a new variant of a natural NRP. However, such chimeric NRPS modules are often...
Nonribosomal peptide synthetases (NRPSs) are giant multi-domain enzymes that catalyse the biosynthesis of many commercially important peptides produced by bacteria and fungi. Several studies over the last decade have shown that many of the individual domains within NRPSs exhibit significant substrate selectivity, which impacts on our ability to engineer NRPSs to produce new bioactive microbial ...
Fungal natural compounds are industrially produced, with application in antibiotic treatment, cancer medications, and crop plant protection. Traditionally, higher fungi have been intensively investigated concerning their metabolic potential, but reidentification of already known is frequently observed. Hence, alternative strategies to acquire novel bioactive molecules required. We present the g...
Nonribosomal peptide synthetases (NRPSs) are large multimodular and multidomain enzymes that are involved in synthesising an array of molecules that are important in human and animal health. NRPSs are found in both bacteria and fungi but most of the research to date has focused on the bacterial enzymes. This is largely due to the technical challenges in producing active fungal NRPSs, which stem...
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