objective(s): yu-ping-feng-san (ypfs) is a classical traditional chinese medicine that is widely used for treatment of the diseases in respiratory systems, including chronic obstructive pulmonary disease (copd) recognized as chronic inflammatory disease. however, the molecular mechanism remains unclear. here we detected the factors involved in transforming growth factor beta 1 (tgf-β1)/smad2 si...

You have accessJournal of UrologyBladder & Urethra: Anatomy, Physiology Pharmacology (MP08)1 Sep 2021MP08-13 MICRORNA-29a REGULATES TGF-β1-INDUCED EXPRESSION OF COLLAGEN 1a1 IN HUMAN UROTHELIAL CELLS Zunyi Wang, Jianghui Hou, and Dale Bjorling WangZunyi Wang More articles by this author , HouJianghui Hou BjorlingDale View All Author Informationhttps://doi.org/10.1097/JU.0000000000001981.13About...

conclusions our study demonstrated that tgf-β1 serum levels is higher in osteoporotic postmenopausal females than non-osteoporotic ones, and probably aberrant increase in tgf-β1 in postmenopausal females can result in uncoupled bone resorption and formation, which leads to osteoporosis. background postmenopausal osteoporosis is a major cause of morbidity in postmenopausal females. transforming ...

Abstract Background and Aims The transforming growth factor-β1 (TGF-β1) is a pleiotropic cytokine, with distinct roles both in fibrosis inflammation acts through the Smad signalling renal injury. We sought expression of TGF-β1/Smad ANCA associated glomerulonephritis (AAGN) we assessed this correlation injury at diagnosis as well progression. Method evaluated immunohistochemical TGF-β1, phosphor...

Transforming growth factor β1 (TGF-β1) is a polypeptide with various biological activities. Recent studies have shown that this and they receptors are expressed in human Leydig cells, Sertoli spermatogonia, spermatocytes sperm cells after birth, involved the endocrine regulation of spermatogenesis. However, there no report on expression TGF-β embryonic testis. TGF-β1 peptide widely distributed ...

background: tnf-α is a multifunctional proinflammatory cytokine and tgf-β1 is a secretory protein controlling epithelial proliferation and differentiation. keratocyst presents an aggressive behavior and a growth mechanism different from that of radicular cyst. aim: in this line, the present study aimed at evaluating tnf-α and tgf-β1 level and its association with histopathological findings in t...

Abstract Glomerular podocytes are integral members of the glomerular filtration barrier in kidney and crucial for permselectivity. These highly differentiated cells vulnerable to an array noxious stimuli that prevail several diseases. Elevated circulating growth hormone (GH) levels associated with podocyte injury proteinuria diabetes. However, precise mechanism(s) by which excess GH elicits pod...

Systemic sclerosis (SSc) is a chronic autoimmune disease, featuring fibrosis in multiple organs. The serum from SSc patients contain inflammatory mediators, contributing to SSc pathogenesis and could be used to develop cell culture models. Here, we compared the fibrotic effects of serum samples from SSc patients with TGFβ1 on human dermal fibroblasts (HDFs). HDF cells were cultured in four diff...