objective(s) this study aimed to investigate and to compare the effects of nifedipine and amlodipine, dihydropyridine (dhp) calcium channel blockers (ccbs) on perfusion pressure of isolated perfused rat kidney. materials and methods following the establishment of renal perfusion with a constant baseline pressure of 85-95 mmhg, the renal vasculature was constricted by phenylephrine (pe) injectio...

background medical sphincterotomy has gained popularity as a treatment for anal fissure. calcium channel blockers in topical forms could also be appropriate with low adverse effects. objectives this was a prospective randomized controlled trial to compare topical and oral nifedipine in the treatment of chronic anal fissure. patients and methods a prospective randomized controlled trial was cond...

intravenous hydralazine is a commonly administered arteriolar vasodilator that is effective for hypertensive emergencies associated with pregnancy. oral nifedipine is an alternative in management of these patients. in this study the efficacy of nifedipine and hydralazine in pregnancy was compared in a group of iranian patients. fifty hypertensive pregnant women were enrolled in the study. a ran...

chronic anal fissure is the most common cause of anal pain associated with internal anal sphincter hypertonia. reduction of hypertonocity is a special treatment for fissure healing. for this purpose chronic anal fissures were conventionally treated by anal dilatation or by lateral sphincterotomy. however, both of these methods may cause a degree of incontinence in some patients. the uptake of m...

objectives in order to provide a pharmacological profile for some newly synthesized dihydropyridines, we investigated their effects on the isolated rat colon segments and the isolated rat atrium contractility. the tested compounds include alkyl ester analogues of nifedipine, in which the ortho-nitrophenyl group at position 4 is replaced by 2-alkylthio-1-benzyl-5-imidazolyl substituent, and nife...

The first line antihypertensive treatment for severe hypertension of pregnancy includes labetalol, hydralazine, or nifedipine. Rapid but safe blood pressure control allows the definitive treatment, delivery baby to be carried out with minimal delay and good maternal fetal outcomes. This non-randomized clinical trial was performed in Faridpur Medical College Hospital compare effectiveness tolera...