This paper describes the advantages of SyD (System on Mobile Devices), a middleware technology for mobile devices and e-services, in terms of technology and programming. Features of SyD are illustrated here through our prototype application, a complex communication system for a trucking fleet that operates an automated package delivery system. The fleet system has been implemented in three ways...

System of Mobile Devices (SyD) is a middleware we developed that can be used for implementing collaborative, mobile, and distributed applications over heterogeneous devices, data stores, and computing environments. Current prototype implementation of SyD consists of five modules. These modules provide ease of programming in the areas of distributed communication, remote method invocation, servi...

Highlighting the importance of proper intracellular organization, many muscle diseases are characterized by mispositioned myonuclei. Proper positioning of myonuclei is dependent upon the microtubule motor proteins, Kinesin-1 and cytoplasmic Dynein, and there are at least two distinct mechanisms by which Kinesin and Dynein move myonuclei. The motors exert forces both directly on the nuclear surf...

Neuronal development, function and repair critically depend on axonal transport of vesicles and protein complexes, which is mediated in part by the molecular motor kinesin-1. Adaptor proteins recruit kinesin-1 to vesicles via direct association with kinesin heavy chain (KHC), the force-generating component, or via the accessory light chain (KLC). Binding of adaptors to the motor is believed to ...

Objectives. The study was to investigate the effects and mechanisms of Shen-Yuan-Dan (SYD) pharmacological postconditioning on myocardial ischemia/reperfusion (I/R) injury. Methods. In the in vivo experiment, myocardial injury markers and histopathology staining were examined. In the in vitro experiment, cell viability and cell apoptosis were, respectively, detected by 3-(4,5-dimethylthiazol-2-...

During development, axons must integrate directional information encoded by multiple guidance cues and their receptors. Axon guidance receptors, such as UNC-40 (DCC) and SAX-3 (Robo), can function individually or combinatorially with other guidance receptors to regulate downstream effectors. However, little is known about the molecular mechanisms that mediate combinatorial guidance receptor sig...

A broadly conserved membrane-associated protein required for the functional interaction of kinesin-I with axonal cargo was identified. Mutations in sunday driver (syd) and the axonal transport motor kinesin-I cause similar phenotypes in Drosophila, including aberrant accumulations of axonal cargoes. GFP-tagged mammalian SYD localizes to tubulovesicular structures that costain for kinesin-I and ...

The polarized trafficking of axonal and dendritic components is essential for the development and maintenance of neuronal structure and function. Neuropeptide-containing dense-core (DCVs) vesicles are trafficked in a polarized manner from the cell body to their sites of release; however, the molecules involved in this process are not well defined. Here we show that the scaffolding protein SYD-2...

the aim of the present study was to investigate the effect of endurance training on syd gene expression in motor neurons of rats with diabetic neuropathy. 12 wistar male rats were randomly assigned to 3 groups (each group 4 subjects): diabetic trained (dt), diabetic untrained (dc) and healthy control (hc). two weeks after stz injection to induce diabetes, diabetic neuropathy was demonstrated by...

SPLAYED (SYD) is a SWItch/Sucrose Non-Fermentable (SWI/SNF)-type chromatin remodeler identified in Arabidopsis thaliana (Arabidopsis). It believed to play both redundant and differential roles with its closest homolog BRAHMA (BRM) diverse plant growth development processes. To better understand how SYD functions, we profiled the genome-wide occupancy of impact on global transcriptome trimethyla...