The initiation of protein synthesis in reticulocyte lysates is inhibited by low levels (1-50 ng/ml) of doublestranded RNA (dsRNA) due to the activation of a CAMPindependent protein kinase (dsI) which phosphorylates the a-subunit (38,000 daltons) of eukaryotic initiation factor 2 (eIF-2a). In lysates, dsI is present in an inactive precursor form (latent dsI) associated with the ribosomal complem...

With the increasing aging population, the number of veterans presenting with dual sensory impairment (DSI) (vision and hearing impairments) will increase. This study determined the prevalence and clinical characteristics of DSI in a veteran population receiving healthcare from the Department of Veterans Affairs (VA). A retrospective review was conducted on 400 charts randomly selected from a da...

Endocannabinoids are lipid derivatives that mediate paracrine and juxtacrine signaling between cells. In the hippocampal CA1 region, a retrograde endocannabinoid signal suppresses GABA release by acting on presynaptic cannabinoid receptor-1 (CB1) and can be functionally manifested as depolarization-induced suppression of inhibition (DSI). In the present study, whole cell patch-clamp recordings ...

Depolarization-induced suppression of inhibition (DSI) is a transient suppression of the inhibitory synaptic transmission, observed in the hippocampus and the cerebellum, upon postsynaptic depolarization. Using rat hippocampal cultures, we examined whether DSI is confined to the inhibitory synapses on the depolarized neuron or, if DSI can spread to those on neighboring non-depolarized neurons. ...

OBJECTIVE The purpose of this study was to investigate the interobserver variability and the test-retest variability of the Dysphonia Severity Index (DSI), a multiparametric instrument to assess voice quality. METHODS The DSI was measured in 30 nonsmoking volunteers without voice complaints or voice disorders by two speech pathologists. The subjects were measured on 3 different days, with an ...

BACKGROUND Deliberate self-injury (DSI) is significantly associated with personality disorder (PD). There are gaps in our knowledge of DSI as an indicator of severity of psychopathology, as moderator of outcome and with regard to its response to different treatment programs and settings. METHODS We compare 2 samples of PD with (n = 59) and without (n = 64) DSI in terms of clinical presentatio...

Whole-cell current-clamp recordings were made from distal dendrites of rat hippocampal CA1 pyramidal cells. Following depolarization of the dendritic membrane by direct injection of current pulses or by back-propagating action potentials elicited by antidromic stimulation, evoked gamma-aminobutyric acid-A (GABA(A)) receptor-mediated inhibitory postsynaptic potentials (IPSPs) were transiently su...

OBJECTIVE To validate, in US community-based colposcopy clinics, previous reports of increased detection of high-grade cervical intraepithelial neoplasia (CIN2+) with biopsies selected using dynamic spectral imaging (DSI) mapping after standard colposcopy. STUDY DESIGN Cross-sectional observational study of 26 colposcopists across nine clinics recruiting consecutive colposcopy patients. Stand...

We report here the silicon isotopic composition (δSi) of dissolved silicon (DSi) from 42 surface water samples from the Drake Passage, the Weddell Gyre, other areas south of the Southern Boundary of the Antarctic Circumpolar Current (ACC), and the ACC near the Kerguelen Plateau, taken between the beginning of February and the end of March 2007. From the beginning to end of the cruise (ANTXXIII/...

Depolarization-induced suppression of inhibition (DSI) is a retrograde form of synaptic inhibition involving the Ca2+-dependent release of cannabinoids from the postsynaptic cell. DSI exerts multiple effects on presynaptic neurons: here, we establish the breakdown of DSI in its individual components at the synapses between basket and stellate cells and Purkinje cells. In the presence of tetrodo...