Seventeen non-directed td- (thymidylate synthase-deficient) splicing-defective mutations isolated in phage T4 were localized within the catalytic core of the ribozyme. All of the mutations occur in conserved structural elements that form part of the td intron core secondary structure. Remarkably, seven of the seventeen independently isolated mutations clustered in the dinucleotide 5' element (P...

Outer membrane protein P6 is the subject of investigation as a vaccine antigen to prevent infections caused by nontypeable Haemophilus influenzae, which causes otitis media in children and respiratory tract infections in adults with chronic lung disease. P6 induces protective immune responses in animal models and is the target of potentially protective immune responses in humans. P6 is a 16-kDa...

Let G be a finite undirected graph. A vertex dominates itself and all its neighbors in G. A vertex set D is an efficient dominating set (e.d. for short) of G if every vertex of G is dominated by exactly one vertex of D. The Efficient Domination (ED) problem, which asks for the existence of an e.d. in G, is known to be NP-complete even for very restricted graph classes such as P7-free chordal gr...

The purpose of this study was to characterize the degree of antigenic heterogeneity or conservation of a 16,600-dalton outer membrane protein (P6) among strains of nontypable Haemophilus influenzae. Immunization of rabbits with P6 isolated from individual strains resulted in antibody to P6 of all 25 strains tested. The titers of antibody in the sera were similar among the strains. Whole organis...

Imagine that you have 6 people at a party. We assume that, for every pair of them, either THEY KNOW EACH OTHER or NEITHER OF THEM KNOWS THE OTHER. So we are assuming that if x knows y, then y knows x. Claim: Either there are at least 3 people all of whom know one another, or there are at least 3 people no two of whom know each other (or both). Proof of Claim: Let the people be p1, p2, p3, p4, p...

The P6 protein of Cauliflower mosaic virus (CaMV) is responsible for the formation of inclusion bodies (IBs), which are the sites for viral gene expression, replication, and virion assembly. Moreover, recent evidence indicates that ectopically expressed P6 inclusion-like bodies (I-LBs) move in association with actin microfilaments. Because CaMV virions accumulate preferentially in P6 IBs, we hy...

Non-typeable Haemophilus influenzae (NTHI) colonizes the lower respiratory tract of patients with chronic obstructive pulmonary disease and also causes exacerbations of the disease. The 16-kDa lipoprotein P6 has been widely studied as a potential vaccine antigen due to its highly conserved expression amongst NTHI strains. Although P6 is known to induce potent inflammatory responses, its role in...

We show that every (P6, diamond, K4)-free graph is 6-colorable. Moreover, we give an example of a (P6, diamond, K4)-free graph G with χ(G) = 6. This generalizes some known results in the literature.

We examine which p-groups of order ≤ p6 are Beauville. We completely classify them for groups of order ≤ p4. We also show that the proportion of 2-generated groups of order p5 which are Beauville tends to 1 as p tends to infinity; this is not true, however, for groups of order p6. For each prime p we determine the smallest non-abelian Beauville p-group.