نتایج جستجو برای: میر 451
تعداد نتایج: 10625 فیلتر نتایج به سال:
رۆژنامهڤانی ئێك ژ ژێده‌رێن گرنگه بۆ په‌یداكرنا پێزانینێن مێژوویێ ل دور هه‌ر بابه‌ته‌كێ گرێدای مێژوویێ، ب تایبەت ئەو رۆژنامە ئەوێن سەردەمی رویدانا دەرچووین، چۆنکە گەلەک دەم سەردا نەچوویە، له‌ورا زۆر ڤه‌كۆلینێن ئه‌كادیمى د ناڤ رۆپه‌لێن ئه‌وانا دا هویرى بهێنه ئه‌نجامدان، چونكه گه‌له‌ك جاران ئه‌و پێزانین دناڤ ئه‌وان رۆژناما بنه جهێ باوه‌ریێ، لێ هه‌مان ده‌م هنده‌ك ئه‌واندا هه‌نه شاشن و دورن را...
microrna ها مولکولهایrna کوچک غیر کدکننده ای هستند که توسطrna pol ii رونویسی شده و پس از پردازشهای مختلف توسط کمپلکسrisc عمل می کنند. نقش این مولکولها در پروسه های متعدد سلولی از قبیل پرولیفراسیون، تمایز، آپوپتوزیس و سرطان اثبات شده است. تمایز سلوهای خونی پروسه پیچیده ای است که فاکتورهای رونویسی مختلف و همچنین mirna های متعدد درآن نقش دارند مطالعات اخیر کاهش سطحmir-155 و افزایشmir-451 را در طی ...
PURPOSE miR-451 is a tumor suppressive microRNA with several target genes, including Macrophage migration inhibitory factor (MIF). As little is known about the expression and clinicopathological significance of mir-451 in NSCLC, we performed a clinicopathological study of 370 NSCLC cases to clarify them. Cell biological experiments were also performed on NSCLC cell lines to confirm the tumor-su...
The microRNAs miR-144 and -451 are encoded by a bicistronic gene that is strongly induced during red blood cell formation (erythropoiesis). Ablation of the miR-144/451 gene in mice causes mild anemia under baseline conditions. Here we show that miR-144/451-/- erythroblasts exhibit increased apoptosis during recovery from acute anemia. Mechanistically, miR-144/451 depletion increases the express...
One fundamental issue in public health is the safety of food products derived from plants and animals. A recent study raised a concern that microRNAs, which widely exist in everyday foods, may alter consumers' functions. However, some studies have strongly questioned the likelihood of dietary uptake of functional microRNAs in mammals. Here we use a microRNA gene knockout animal model to show th...
BACKGROUND Recently, miR-451 as a tumor suppressor has been reported in other studies. However, whether miR-451 can affect the sensitivity of non-small cell lung cancer (NSCLC) cells to cisplatin (DDP) remains unclear. The aim of this study is to evaluate the roles of miR-451 in the sensitivity of NSCLC cells to DDP. METHODS Quantitative RT-PCR assay was performed to detect the expression of ...
BACKGROUND Renal cell carcinoma (RCC) is a common cancer, accounting for about 2-3% of all adult cancers. A novel diagnostic biomarker and therapeutic target is urgently needed. However, the function of miR-451 in RCC remains unknown. Here, we explored the role of miR-451 in RCC. MATERIAL/METHODS MiR-451 levels in RCC tissues and cells were tested by qRT-PCR. Cells were transfected miR-451 mi...
Malignant hepatoma is the leading cause of morbidity and mortality in primary liver cancer. MicroRNAs are widely accepted to act as tumor regulators to mediate tumorigenesis. Recently, miRNA-451 (miR-451) has attracted increasing attention due to its critical roles in the development of several types of cancers. Unfortunately, its function and underlying mechanism(s) of action in hepatoma remai...
MicroRNA (miR)-451 is a cell metabolism-related miRNA that can mediate cell energy-consuming models by several targets. As miR-451 can promote mechanistic target of rapamycin (mTOR) activity, and increased mTOR activity is related to increased differentiation of T-helper 17 (Th17) cells, we sought to investigate whether miR-451 can redistribute from cancer cells to infiltrated T cells and enhan...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید