Modified cyclic dipeptides represent a diverse family of microbial secondary metabolites. They display a broad variety of biological and pharmacological activities and have long been recognized as privileged structures with the ability to bind to a wide range of receptors. This is due to their conformationally constrained 2, 5-diketopiperazine (DKP) scaffold and the diverse set of DKP tailoring...

Histidyl-proline diketopiperazine (His-Pro DKP) cells in the pancreas of human fetuses aged between 12 and 19 wk were localized by the indirect antibody-enzyme method on semithin sections. To study their fine structure, two techniques were used: a superimposition technique consisting of comparison of the same cells in semithin and electron microscopic preparations, and an immunocytochemical tec...

In this paper, we present the results obtained by our DKP-AOM system within the OAEI 2016 campaign. DKPAOM is an ontology merging tool designed to merge heterogeneous ontologies. In OAEI, we have participated with its ontology mapping component which serves as a basic module capable of matching large scale ontologies before their merging. This is our second successful participation in the OAEI ...

We present two constructions of new solutions to the dispersionless KP (dKP) equation arising from the first two Painlevé transcendents. The first construction is a hodograph transformation based on Einstein–Weyl geometry, the generalised Nahm's equation and the isomonodromy problem. The second construction, motivated by the first, is a direct characterisation of solutions to dKP which are cons...

We present two constructions of new solutions to the dispersionless KP (dKP) equation arising from the first two Painlevé transcendents. The first construction is a hodograph transformation based on Einstein–Weyl geometry, the generalised Nahm's equation and the isomonodromy problem. The second construction, motivated by the first, is a direct characterisation of solutions to dKP which are cons...

A strategy for the synthesis of members of the prenylated indole alkaloid family is described, which involves a radical cascade process of an appropriately substituted diketopiperazine (DKP) core structure. Several approaches to the generation of the initial radical were explored, with the most successful involving treatment of a sulfenyl substituted DKP under classical reductive conditions by ...

A cognitive approach for kinodynamic trajectory planning In this thesis, I present two new contributions. First, I provide DKP: a sample-based approach for trajectory planning. DKP uses a selection/propagation architecture to build an exploration tree in the reachable parts of the environment, guided in an A manner. Solutions are quadratic spline trajectories that are immediately executable by ...

BACKGROUND Cyclic RGD peptidomimetics containing a bifunctional diketopiperazine scaffold are a novel class of high-affinity ligands for the integrins αVβ3 and αVβ5. Since integrins are a promising target for the modulation of normal and pathological angiogenesis, the present study aimed at characterizing the ability of the RGD peptidomimetic cyclo[DKP-RGD] 1 proliferation, migration and networ...

The pathway of dehydration and intramolecular cyclization of lisinopril dihydrate in the solid state was investigated using differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and a combination of thermal analyzer with Fourier transform infrared microspectroscopy (thermal FT-IR microscopic system). The results indicate that the dehydration from the solid-state lisinopril d...

The interaction of a small library of cyclic DKP-RGD peptidomimetics with α5β1 integrin has been investigated by means of an integrated experimental and computational approach. Bioaffinity NMR techniques, including saturation transfer difference (STD) and transferred NOESY, were applied to the ligands in a suspension of intact MDA-MB-231 breast cancer cells, in which integrin α5β1 is highly exp...