Actinic keratosis (AK) is an early stage of evolving skin cancer and may be classified as a squamous cell carci-noma (SCC) in situ, which originates from keratinocytes and appears on areas of skin exposed to sunlight, such as the face and arms. It is a common condition in the general population, with prevalence increasing with age and cumulative sun exposure. The American Academy of Dermatology...

BACKGROUND Actinic keratoses (AKs) are epidermal skin lesions with the potential to develop into invasive squamous cell carcinoma (SCC). Treatment at an early stage may prevent development of SCC. Current treatment options are highly destructive and associated with significant side-effects. Early studies with topical diclofenac were encouraging and led to its evaluation for the treatment of act...

tracheal injection of ovalbumin-fluorescein isothiocyanate (FITC) or ovalbumin and were killed at varying time points thereafter depending on the aspect of DC function being studied (migration, maturation, or T-cell activation). Lung cells were isolated, and the numbers of DCs were determined in exposed and unexposed mice by flow cytometry. Migration of lung DCs to thoracic lymph nodes (TLNs) w...

Previous research has shown that prior exposure to a word's substitution neighbor earlier in the same sentence can disrupt processing of that word, indicating that interword lexical priming occurs naturally during reading, due to the competition between lexical candidates during word identification. Through the present research, we extended these findings by investigating the effects of prior e...

Allograft transplantation into sensitized recipients with antidonor antibodies results in accelerated antibody-mediated rejection (AMR), complement activation, and graft thrombosis. We have developed a membrane-localizing technology of wide applicability that enables therapeutic agents, including anticoagulants, to bind to cell surfaces and protect the donor endothelium. We describe here how th...

به‌منظور تحلیل نوترونیک قلب رآکتورها، نیاز به توسعه نرم‌افزارهای محاسبات هسته‌ای جهت تولید ثابت‌های چند گروهی و حل عددی معادله پخش است. برای این منظور، از روش‌هایی استفاده می‌شود که علاوه بر دقت مناسب حجم زمان بهینه‌ای برخوردار باشند. در پژوهش تئوری حاکم روش نودال بسط شار جریان متوسط هم‌چنین مرتبه‌های بالاتر پرداخته می‌شود. پس‌ازآن با گسسته‌سازی نوترون، نشان داده روش‌ بهینه خوبی بهره می‌برد. مس...

امروزه در مبحث محاسبات رآکتورهای هسته‌ای مثل فرسایش و مدیریت سوخت، تحلیل گذرا بازسازی توان میله‌های به دنبال روش‌هایی جهت استفاده کدهای هستند که علاوه بر دقت قابل‌قبول از هزینه زمان بهینه‌ای برخوردار باشند. این پژوهش با گسسته‌سازی معادله پخش نوترون روش نودال بسط شار جریان ‌متوسط مرتبه بالا نشان داده می‌شود روش‌ بهینه قابل‌قبولی بهره می‌برد. مستقیم الحاقی نوترون، برای هندسه مربعی دوبعدی دو گروه ...