Drugs and other chemicals frequently bind nonspecifically to the constituents of an in vitro incubation mixture, particularly the enzyme source [e.g., human livermicrosomes (HLM)]. Correction for nonspecific binding (NSB) is essential for the accurate calculation of the kinetic parameters Km, Clint, and Ki. Many tyrosine kinase inhibitors (TKIs) are lipophilic organic bases that are nonionized ...

H LM software has been one of the leading statistical packages for hierarchical linear modeling due to the pioneering work of Stephen Raudenbush and Anthony Bryk, who created the software and authored the leading text on hierarchical linear and nonlinear modeling (Bryk & Raudenbush, 1992; Raudenbush & Bryk, 2002). Though differences among software packages’ capabilities have diminished over tim...

This work analyses the application of heuristic algorithms in the transmission network expansion planning problem using the Hybrid Linear Model (HLM). The HLM is a relaxed model which still has not been fully explored. The work presents a detailed study of a constructive heuristic algorithm for the HLM and proposes an extension of the model and a solution technique for multi-stage planning. Qua...

This communication introduces HLM-Tetis, which is a model structure coupled to the Hillslope Link Model (HLM) framework developed by Iowa Flood Center. The was designed improve some limitations of previous HLM structures. following changes have been made: (1) modules simulate snow processes; (2) better flexibility infiltration and percolation; (3) more derive total runoff from partitioning over...

Drugs and other chemicals frequently bind nonspecifically to the constituents of an in vitro incubation mixture, particularly the enzyme source [e.g., human livermicrosomes (HLM)]. Correction for nonspecific binding (NSB) is essential for the accurate calculation of the kinetic parameters Km, Clint, and Ki. Many tyrosine kinase inhibitors (TKIs) are lipophilic organic bases that are nonionized ...

Previous publications on hierarchical linear modeling (HLM) have provided guidance on how to perform the analysis, yet there is relatively little information on two questions that arise even before analysis: Does HLM apply to one’s data and research question? And if it does apply, how does one choose between HLM and other methods sometimes used in these circumstances, including multiple regress...

BACKGROUND Off-pump-coronary-artery-bypass-grafting (OPCAB) and minimized-extracorporeal-circulation (Mini-HLM) have been proposed to avoid harmful effects of cardiopulmonary-bypass (CPB). Controversies exist whether OPCAB is still superior in perioperative outcome. Circulating endothelial cells (CEC) are sensitive markers of endothelial damage and are significantly elevated in conventional-CPB...

Tryptamine is a trace amine in mammalian central nervous system that interacts with the trace amine TA(2) receptor and is now thought to function as a neurotransmitter or neuromodulator. It had been reported that deamination of tryptamine to tryptophol was mediated by CYP2D6, a cytochrome P450 that is expressed in human brain, suggesting that tryptamine may be an endogenous substrate for this p...

Drugs and other chemicals frequently bind nonspecifically to the constituents of an in vitro incubation mixture, particularly the enzyme source [e.g., human livermicrosomes (HLM)]. Correction for nonspecific binding (NSB) is essential for the accurate calculation of the kinetic parameters Km, Clint, and Ki. Many tyrosine kinase inhibitors (TKIs) are lipophilic organic bases that are nonionized ...

The present research proposes the hierarchical linear modeling model (HLM) that describe how green social responsibility (GSR) predict environmental strategy (ES) of agricultural technology manufacturing companies by intermediary effects supervisor’s promise (GP) based on symbolic context theory. This study collected data with 150 supervisors from 50 different in Taiwan to analyze HLM. results ...