Increasingly restrictive emission regulations and renewed focus on energy efficiency drive the current researches to find alternative fuels and their related better combustion strategies. In this regard, dual fuel engines, in which natural gas fuel is used as a main fuel and diesel fuel is employed as a pilot fuel, have received considerable attention. However, poor fuel utilization efficiencie...

nitrogen oxides (nox) contribute to a wide range of environmental effects including the formation of acid rain and destroy ozone layer. in-cylinder high temperature flame and high oxygen concentration are the parameters which affect the nox emissions. the egr system is a very effective way for reducing nox emission from a diesel engine (via reduction of these parameters), particularly at the hi...

Stimulation of astrocytes with epidermal growth factor (EGF) induced proliferation and triggered the biosynthesis of the transcription factor Egr-1, involving the activation of the extracellular signal-regulated protein kinase (ERK) signaling pathway. No differences in the proliferation rate of astrocytes prepared from wild-type or Egr-1-deficient mice were detected. However, expression of a do...

In septic shock, tissue factor (TF) activates blood coagulation, and cytokines and chemokines orchestrate an inflammatory response. In this study, the role of Egr-1 in lipopolysaccharide (LPS) induction of TF and inflammatory mediators in vivo was evaluated using Egr-1(+/+) and Egr-1(-/-) mice. Administration of LPS transiently increased the steady-state levels of Egr-1 mRNA in the kidneys and ...

In order to search for genes that are activated by muscarinic acetylcholine receptors (mAChRs), we used an mRNA differential display approach in HEK293 cells expressing m1AChR. The zinc-finger transcription factor genes Egr-1, Egr-2, and Egr-3 were identified. Northern blot analyses confirmed that mRNA levels of Egr-1, Egr-2, and Egr-3 increased readily after m1AChR stimulation and that a maxim...