Eukaryotic flagella and cilia are surrounded by a membrane that is continuous with, but distinct from, the rest of the plasma membrane. In Leishmania parasites, the inner leaflet of the flagellar membrane is coated with the acylated membrane protein, SMP-1. Here, we provide evidence that SMP-1 stabilizes the flagellar membrane and is required for flagella elongation and function. The expression...

BACKGROUND This study evaluated the measurement properties of a newly developed instrument - the Self-Management Profile for Type 2 Diabetes (SMP-T2D). METHODS The 18-item SMP-T2D assesses 12 constructs: level and perceived ease of performance in five self-care domains (blood glucose monitoring, medication-taking, healthy eating, being physically active, and coping), and two global constructs...

SOAP, a de-facto communication protocol of Web services, is popular for its interoperability across organisations. However, SOAP is based on XML and therefore inherits XML’s disadvantage of having voluminous messages. When there are many transactions requesting similar server operations, using conventional SOAP unicast to send SOAP response messages can generate a very large amount of traffic [...

The procarcinogen 1-methylpyrene is activated by hepatic enzymes via 1-hydroxymethylpyrene to 1-sulfooxymethylpyrene (1-SMP), a highly reactive and mutagenic metabolite. Previously, high levels of 1-SMP DNA adducts were observed in rat kidneys after intraperitoneal administration of 1-hydroxymethylpyrene or 1-SMP. This study examined whether organic anion transporters (OAT) that are expressed a...

The maximum stable matching problem (Max-SMP) and the minimum stable matching problem (Min-SMP) have been known to be NP-hard for subcubic bipartite graphs, while Max-SMP can be solved in polynomal time for a bipartite graph G with a bipartition (X,Y ) such that degG(v) ≤ 2 for any v ∈ X. This paper shows that both Max-SMP and Min-SMP can be solved in linear time for trees. This is the first po...

A learner’s modifiable components are called its policy. An algorithm that modifies the policy is a learning algorithm. If the learning algorithm has modifiable components represented as part of the policy, then we speak of a self-modifying policy (SMP). SMPs can modify the way they modify themselves etc. They are of interest in situations where the initial learning algorithm itself can be impr...