An in vitro transcription assay was used to compare the capacity of the bisintercalating anthracycline WP631 (which displays a remarkably high DNA-binding affinity) and the monointercalating anthracycline daunomycin to inhibit transcription initiation of the adenovirus major late promoter linked to a G-less transcribed DNA template. Both drugs inhibit basal RNA synthesis in a concentration-depe...

The application of detailed structural data bases has now culminated in the successful design of a new generation of bisanthracyclines that form ultratight DNA complexes [Chaires, J. B., Leng, F., Przewloka, T., Fokt, I., Ling, Y. H., Perez-Soler, R., & Priebe, W. (1997) J. Med. Chem. 40, 261-266]. Daunomycin dimers were designed to bind to DNA in complexes resembling those of monomers intercal...

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1 Algebraic sets, affine varieties, and the Zariski topology 4 1.1 Algebraic sets . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 1.2 Hilbert basis theorem . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 1.3 Zariski topology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 1.3.1 Proof that affine algebraic sets form closed sets on a t...

We construct Hadamard matrices of orders 4 · 251 = 1004 and 4 · 631 = 2524, and skewHadamard matrices of orders 4 · 213 = 852 and 4 · 631 = 2524. As far as we know, such matrices have not been constructed previously. The constructions use the GoethalsSeidel array, suitable supplementary difference sets on a cyclic group and a new efficient matching algorithm based on hashing techniques.

The 72-kDa gelatinase/type IV collagenase, a metalloproteinase thought to play a role in metastasis and in angiogenesis, forms a noncovalent stoichiometric complex with the tissue inhibitor of metalloproteinase-2 (TIMP-2), a potent inhibitor of enzyme activity. To define the regions of the 72-kDa gelatinase responsible for TIMP-2 binding, a series of NH2- and COOH-terminal deletions of the enzy...

Combinatorics, Probability and Computing / Volume 20 / Issue 04 / July 2011, pp 631 640 DOI: 10.1017/S0963548311000204, Published online: 31 May 2011 Link to this article: http://journals.cambridge.org/abstract_S0963548311000204 How to cite this article: BAOGANG XU and XINGXING YU (2011). Better Bounds for k-Partitions of Graphs. Combinatorics, Probability and Computing, 20, pp 631-640 doi:10.1...

CATALYTICALLY ACTIVE CLOSTRIDIUM BOTULINUM NEUROTOXIN E Rakhi Agarwal and Subramanyam Swaminathan Biology Department, Brookhaven National Laboratory, Upton, New York 11973 USA Running title: Crystal structure of BoNT E -SNAP-25 peptide complex Corresponding author: S. Swaminathan, Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Phone-1(631)344-3187, Fax: 1(631)344-3407...

objective: multiple sclerosis (ms) is a chronic autoimmune disease due to demyelination of the central nervous system. it is believed that cytokines are involved in the pathogenesis of ms. the interleukin-2 (il2) gene is powerful functional candidate that is involved in immune regulation and operation. in this study, for the first time, we investigated the effect of -475 a/t and -631 g/a il2 po...