Sphingosine kinase 1 (SK1) plays an important role in estrogen-dependent breast tumorigenesis, but its regulation is poorly understood. A subset of microRNAs (miRNA, miR) is regulated by estrogen and contributes to cellular proliferation and cancer progression. Here, we describe that miR-515-5p is transcriptionally repressed by estrogen receptor α (ERα) and functions as a tumor suppressor in br...

Here, we show that miR-515-5p inhibits cancer cell migration and metastasis. RNA-seq analyses of both oestrogen receptor receptor-positive and receptor-negative breast cancer cells overexpressing miR-515-5p reveal down-regulation of NRAS, FZD4, CDC42BPA, PIK3C2B and MARK4 mRNAs. We demonstrate that miR-515-5p inhibits MARK4 directly 3' UTR interaction and that MARK4 knock-down mimics the effect...

Dysregulation of human trophoblast invasion and differentiation can result in preeclampsia (PE), a hypertensive disorder of pregnancy with significant morbidity and mortality for mother and offspring. miRNA microarray analysis of RNA from human cytotrophoblasts (CytT), before and after differentiation to syncytiotrophoblast (SynT) in primary culture, revealed that members of miR-515 family-incl...

Sphingosine kinase 1 (SK1) plays an important role in estrogen-dependent breast tumorigenesis, but its regulation is poorly understood. A subset ofmicroRNAs (miRNA,miR) is regulated by estrogen and contributes to cellular proliferation and cancer progression. Here, we describe that miR-515-5p is transcriptionally repressed by estrogen receptora (ERa) and functions as a tumor suppressor in breas...

در بررسی­های فونستیک سال 2011 دامنه جنوبی رشته کوه­های زاگرس ایران، یک نمونه ماده از گونه Amphipyra kautti Hacker, 2002 متعلق به خانواده Noctuidae و زیرخانواده Amphipyrinae مناطق کوهستانی استان کهگیلویه بویراحمد جمع­ آوری شناسایی شد. این که برای اولین بار ایران گزارش می­شود، همراه با ویژگی­های افتراقی، تصویر الگوی بال اندام تناسلی شده ارائه است. اطلاعات مربوط دیگر همین جنس مطالعه نیز

Spontaneous antispiral wave formation was observed during the simulation of typical reaction-diffusion systems using differential equations models. The equations for the FitzHugh-Nagumo (FHN), complex Ginzburg-Landau (CGL) and the two-variable Oregonator models were integrated using Runge-Kutta methods. It was found that antispiral waves can occur only near the Hopf bifurcation, i.e. the point ...