RATIONALE Sustained cardiac hypertrophy is often accompanied by maladaptive cardiac remodeling leading to decreased compliance and increased risk for heart failure. Maladaptive hypertrophy is considered to be a therapeutic target for heart failure. MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) have various biological functions and have been extensively investigated in past years. OBJEC...

MicroRNAs have been implicated in ischemic AKI. However, the specific microRNA species that regulates ischemic kidney injury remains unidentified. Our previous microarray analysis revealed microRNA-489 induction in kidneys of mice subjected to renal ischemia-reperfusion. In this study, we verified the induction of microRNA-489 during ischemic AKI in mice and further examined the underlying mech...

Total synthesis of spider toxins HO-416b (1) and Agel-489 (2) was accomplished using the 2-nitrobenzenesulfonamide (Ns) group as both a protecting and activating group. In this strategy, the C-N bonds were constructed by alkylation of sulfonamides with alkyl halides or Mitsunobu reaction with the corresponding alcohol. Beginning with monoprotection of the symmetrical diamine, the construction o...

The in vivo efficacy of piperacillin in combination with the penem inhibitor BLI-489 was determined using acute lethal systemic infections in mice. On the basis of preliminary results with various ratios, a dosing ratio of 8:1 was found to be optimal for retention of enhanced efficacy. Piperacillin-BLI-489 dosed at an 8:1 ratio was efficacious against murine infections caused by class A (includ...

Human epidermal growth factor receptor 2 (HER2 or ErBb2) is a receptor tyrosine kinase overexpressed in 20-30% of breast cancers and associated with poor prognosis and outcome. Dysregulation of several microRNAs (miRNAs) plays a key role in breast cancer progression and metastasis. In this study, we screened and identified miRNAs dysregualted in HER2-positive breast cancer cells. Our molecular ...

Silicosis is an incurable occupational disease associated with inflammation, fibroblast proliferation and the accumulation of extracellular matrix in lung tissues. The dysregulation of lncRNAs and miRNAs has been implicated in many complex diseases; however, the current understanding of their roles in fibrotic lung diseases, especially silicosis, remains limited. Our previous microRNA (miRNA, m...

A large fraction of mammalian genomes is transcribed into noncoding RNAs. 1 Despite the prevalence in the genome, up until recently, noncoding RNAs were regarded as junk RNAs that do not code for protein and, thereby, have no biological purpose. However, over the past decade, it has become increasingly evident that noncoding RNAs can and do serve important regulatory functions in pathophysiolog...

در بررسی­های فونستیک سال 2011 دامنه جنوبی رشته کوه­های زاگرس ایران، یک نمونه ماده از گونه Amphipyra kautti Hacker, 2002 متعلق به خانواده Noctuidae و زیرخانواده Amphipyrinae مناطق کوهستانی استان کهگیلویه بویراحمد جمع­ آوری شناسایی شد. این که برای اولین بار ایران گزارش می­شود، همراه با ویژگی­های افتراقی، تصویر الگوی بال اندام تناسلی شده ارائه است. اطلاعات مربوط دیگر همین جنس مطالعه نیز